国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2013年
16期
1223-1225
,共3页
特发性肺纤维化%血必净注射液%肺功能
特髮性肺纖維化%血必淨註射液%肺功能
특발성폐섬유화%혈필정주사액%폐공능
Idiopathic pulmonary fibrosis%Xuebijing injection%Lung function
目的 观察应用血必净注射液联合泼尼松治疗特发性肺纤维化(IPF)的临床效果.方法 2005年至2012年确诊为IPF的患者共36例,分为2组,对照组18例,单用泼尼松；联合组18例,泼尼松治疗基础上加用血必净注射液,静脉滴注,连用7d,对两组分别进行临床表现、肺功能比较.结果 治疗前,两组患者肺功能参数比较差异无统计学意义,治疗后联合组患者咳嗽、呼吸困难改善的总有效率(77.78％)较对照组(55.56％)提高(P＜0.05)；联合组患者肺活量占预计值百分比(76.92％±20.33％)、肺总量占预计值百分比(83.89％±21.39％)和肺一氧化碳弥散量占预计值百分比(74.58％±21.12％)较治疗前(61.08％±19.11％、66.38％±18.64％和51.33％±20.61％)改善(P＜0.05),且与治疗后对照组(73.24％±20.19％、72.29％±19.78％和71.66％±21.01％)相比,联合组患者改善更明显(P ＜0.05).结论 与单用泼尼松治疗相比,血必净注射液联合泼尼松可进一步改善IPF的治疗效果.
目的 觀察應用血必淨註射液聯閤潑尼鬆治療特髮性肺纖維化(IPF)的臨床效果.方法 2005年至2012年確診為IPF的患者共36例,分為2組,對照組18例,單用潑尼鬆；聯閤組18例,潑尼鬆治療基礎上加用血必淨註射液,靜脈滴註,連用7d,對兩組分彆進行臨床錶現、肺功能比較.結果 治療前,兩組患者肺功能參數比較差異無統計學意義,治療後聯閤組患者咳嗽、呼吸睏難改善的總有效率(77.78％)較對照組(55.56％)提高(P＜0.05)；聯閤組患者肺活量佔預計值百分比(76.92％±20.33％)、肺總量佔預計值百分比(83.89％±21.39％)和肺一氧化碳瀰散量佔預計值百分比(74.58％±21.12％)較治療前(61.08％±19.11％、66.38％±18.64％和51.33％±20.61％)改善(P＜0.05),且與治療後對照組(73.24％±20.19％、72.29％±19.78％和71.66％±21.01％)相比,聯閤組患者改善更明顯(P ＜0.05).結論 與單用潑尼鬆治療相比,血必淨註射液聯閤潑尼鬆可進一步改善IPF的治療效果.
목적 관찰응용혈필정주사액연합발니송치료특발성폐섬유화(IPF)적림상효과.방법 2005년지2012년학진위IPF적환자공36례,분위2조,대조조18례,단용발니송；연합조18례,발니송치료기출상가용혈필정주사액,정맥적주,련용7d,대량조분별진행림상표현、폐공능비교.결과 치료전,량조환자폐공능삼수비교차이무통계학의의,치료후연합조환자해수、호흡곤난개선적총유효솔(77.78％)교대조조(55.56％)제고(P＜0.05)；연합조환자폐활량점예계치백분비(76.92％±20.33％)、폐총량점예계치백분비(83.89％±21.39％)화폐일양화탄미산량점예계치백분비(74.58％±21.12％)교치료전(61.08％±19.11％、66.38％±18.64％화51.33％±20.61％)개선(P＜0.05),차여치료후대조조(73.24％±20.19％、72.29％±19.78％화71.66％±21.01％)상비,연합조환자개선경명현(P ＜0.05).결론 여단용발니송치료상비,혈필정주사액연합발니송가진일보개선IPF적치료효과.
Obiective To observe the effect of Xuebijing injection and prednisone on the patients with idiopathic pulmonary fibrosis (IPF).Methods 36 patients with IPF were randomly divided into control group (18 patients) and combination group (18 patients).All patients were treated with prednisone,besides the combination group was added with Xuebijing injection for seven days.Clinical manifestations and pulmonary function were observed.Results The lung function parameters of the two groups were indifferent before therapy.After therapy,the clinical improvement rate in combination group (77.78％) was higher than that in control group (55.56％,P ＜ 0.05).Compared with pre-therapy (61.08％ ± 19.11％,66.38％ ± 18.64％,and 51.33％ ± 20.61％),VC％ pred (76.92％ ± 20.33％),TLC％ pred (83.89 ％ ± 21.39 ％),and DLCO％ pred (74.58％ ± 21.12 ％) improved after therapy in combination group (P ＜0.05).The improvement in combination group was more effective than that in control group (73.24％ ± 20.19％,72.29％ ± 19.78％,71.66％ ± 21.01％) (P ＜0.05).Conclusions Compared with prednisone treatment only,there is obvious therapeutic effect with Xuebijing injection and prednisone in IPF.
