CAJ | 학술논문

目的探讨脉冲振荡肺功能(IOS)评价尘肺患者肺功能的临床价值.方法对119例尘肺患者和79例健康者依次进行IOS及PFT检测,分析两组人群两种肺功能各项指标之间的差异、相关性.结果对于早期(壹期)尘肺组,PFT中FEV1、FVC、FEV1/FVC、MVV较健康对照组无明显差异,MEF25、MEF50、MEF75则明显降低,差异有统计学意义(P＜0.05)；而IOS参数中Z5、X5、AX明显升高,差异有统计学意义(P＜0.05).在PFT正常的尘肺患者中,壹期尘肺组的IOS参数较健康对照组无明显差异,而贰叁期尘肺组的Z5、X5、Fres则明显升高,差异有统计学意义(P＜0.05)；壹期尘肺组和贰叁期尘肺组IOS异常率均较PFT高,差异有统计学意义(P＜0.05)；IOS参数Z5、R5、R20、R5-R20、Fres、AX与PFT指标FVC、FEV1、FEV1/FVC、MVV、MEF25、MEF50、MEF75呈负相关,X5则呈正相关,两种肺功能指标相关系数(绝对值)按由高到低依次为:Fres与FEV1/FVC(r=-0.566)、Fres与FEV1(r=-0.557)、Z5与FEV1/FVC(r=-0.544)、AX与FEV1/FVC(r=-0.541)、R5与FEV1/FVC(r=-0.541),在贰叁期尘肺组中相关性更高.结论 IOS可以发现早期尘肺患者的气道阻力异常,其操作简便、对受检者配合度要求低,可能是尘肺患者肺功能评价的有益补充.
목적 탐토맥충진탕폐공능(IOS)평개진폐환자폐공능적림상개치.방법 대119례진폐환자화79례건강자의차진행IOS급PFT검측,분석량조인군량충폐공능각항지표지간적차이、상관성.결과 대우조기(일기)진폐조,PFT중FEV1、FVC、FEV1/FVC、MVV교건강대조조무명현차이,MEF25、MEF50、MEF75칙명현강저,차이유통계학의의(P＜0.05)；이IOS삼수중Z5、X5、AX명현승고,차이유통계학의의(P＜0.05).재PFT정상적진폐환자중,일기진폐조적IOS삼수교건강대조조 무명현차이,이이참기진폐조적Z5、X5、Fres칙명현승고,차이유통계학의의(P＜0.05)；일기진폐조화이참기진폐조IOS이상솔균교PFT고,차이유통계학의의(P＜0.05)；IOS삼수Z5、R5、R20、R5-R20、Fres、AX여PFT지표FVC、FEV1、FEV1/FVC、MVV、MEF25、MEF50、MEF75정부상관,X5칙정정상관,량충폐공능지표상관계수(절대치)안유고도저의차위:Fres여FEV1/FVC(r=-0.566)、Fres여FEV1(r=-0.557)、Z5여FEV1/FVC(r=-0.544)、AX여FEV1/FVC(r=-0.541)、R5여FEV1/FVC(r=-0.541),재이참기진폐조중상관성경고.결론 IOS가이발현조기진폐환자적기도조력이상,기조작간편、대수검자배합도요구저,가능시진폐환자폐공능평개적유익보충.
Objective To investigate the application of impulse oscillometry system(IOS) in the measurement of pneumoconiosis.Methods One hundred and ninteen patients with pneumoconiosis and 79 healthy controls were selected randomly to perform IOS and pulmonary function test (PFT) respectively,analysed the difference and correlation of IOS and PFT.Results There were no significant differences in FEV1,FVC,FEV1/FVC and MVV between patients with first-stage pneumoconiosis and healthy controls,but significantly decreased in MEF25,MEF50,MEF75 and increased in Z5,X5,AX for patients (P ＜0.05).There were no significant differences in IOS parameters between patients with first-stage pneumoconiosis whose PFT indices were normal and healthy controls,but significantly increased in Z5,X5,Fres for patients with moderate and severe pneumoconiosis (P ＜ 0.05).Abnormal rate of IOS of mild or moderate-severe pneumoconiosis was significantly higher than PFT.Z5,R5,R20,R5-R20,Fres,AX were negatively correlated with FVC,FEV1,FEV1/FVC,MVV,MEF25,MEF50,MEF75,reversely,but X5 was positively correlated (P ＜0.05) Correlation coefficient from high to low were Fres with FEV1/FVC(r =-0.566),Fres with FEV1 (r =-0.557),Z5 with FEV1/FVC(r =-0.544),AX with FEV1/FVC(r =-0.541),R5 with FEV1/FVC(r =-0.541).Relevance was higher in moderate-severe pneumoconiosis than mild.Conclusions IOS may detect the high airway resistance in mild pneumoconiosis,and performed easily and requires less degree of adaptability,so it may be of value for the evalution of pulmonary function of pneumoconiosis.