国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2013年
19期
1445-1448
,共4页
周国忠%沈巨信%王昊晟%秦娥%孙荷%董学君
週國忠%瀋巨信%王昊晟%秦娥%孫荷%董學君
주국충%침거신%왕호성%진아%손하%동학군
哮喘%呼出气冷凝液%白三烯%前列腺素异构体%孟鲁斯特
哮喘%呼齣氣冷凝液%白三烯%前列腺素異構體%孟魯斯特
효천%호출기냉응액%백삼희%전렬선소이구체%맹로사특
Asthma%Exhaled breath condensates%Leukotriene C4%8-isoprostane%Montelukast
目的 探讨支气管哮喘(简称哮喘)患者治疗前后呼出气冷凝液(EBC)中白三烯C4(LTC4)、8-异前列腺素(8-ISO)、硝酸盐(NO-3)水平及临床意义.方法 酶法和比色法对30例哮喘患者EBC中LTC4、8-ISO、NO-3进行检测,30例健康者作为对照.结果 哮喘患者的LTC4比对照组显著升高(55.17 ng/L比17.95 ng/L,P＜0.01),持续期比间歇期组显著升高(67.38 ng/L比41.21 ng/L,P＜0.01),持续期比对照组显著升高(67.38 ng/L比17.95 ng/L,P＜0.01),间歇期比对照组显著升高(41.21 ng/L比17.95 ng/L,P＜0.01),患者组比治疗后组显著升高(55.17 ng/L比38.36 ng/L,P＜0.01).哮喘患者的8-ISO比对照组显著升高(13.41 ng/L比6.93 ng/L,P＜0.01),持续期组比对照组显著升高(14.29 ng/L比6.93 ng/L,P＜0.01),间歇期比对照组显著升高(12.40ng/L比6.93 ng/L,P＜0.05).哮喘患者的NO-3比对照组显著升高(4.17 ng/L比3.20 ng/L,P＜0.01),持续期组比对照组显著升高(4.50 ng/L比3.20 ng/L,P＜0.01).结论 LTC4、8 ISO、NO-3水平能够很好的体现出哮喘患者的气道炎症水平,而孟鲁斯特药物能够很好的控制气道炎症水平,缓解气道炎症.
目的 探討支氣管哮喘(簡稱哮喘)患者治療前後呼齣氣冷凝液(EBC)中白三烯C4(LTC4)、8-異前列腺素(8-ISO)、硝痠鹽(NO-3)水平及臨床意義.方法 酶法和比色法對30例哮喘患者EBC中LTC4、8-ISO、NO-3進行檢測,30例健康者作為對照.結果 哮喘患者的LTC4比對照組顯著升高(55.17 ng/L比17.95 ng/L,P＜0.01),持續期比間歇期組顯著升高(67.38 ng/L比41.21 ng/L,P＜0.01),持續期比對照組顯著升高(67.38 ng/L比17.95 ng/L,P＜0.01),間歇期比對照組顯著升高(41.21 ng/L比17.95 ng/L,P＜0.01),患者組比治療後組顯著升高(55.17 ng/L比38.36 ng/L,P＜0.01).哮喘患者的8-ISO比對照組顯著升高(13.41 ng/L比6.93 ng/L,P＜0.01),持續期組比對照組顯著升高(14.29 ng/L比6.93 ng/L,P＜0.01),間歇期比對照組顯著升高(12.40ng/L比6.93 ng/L,P＜0.05).哮喘患者的NO-3比對照組顯著升高(4.17 ng/L比3.20 ng/L,P＜0.01),持續期組比對照組顯著升高(4.50 ng/L比3.20 ng/L,P＜0.01).結論 LTC4、8 ISO、NO-3水平能夠很好的體現齣哮喘患者的氣道炎癥水平,而孟魯斯特藥物能夠很好的控製氣道炎癥水平,緩解氣道炎癥.
목적 탐토지기관효천(간칭효천)환자치료전후호출기냉응액(EBC)중백삼희C4(LTC4)、8-이전렬선소(8-ISO)、초산염(NO-3)수평급림상의의.방법 매법화비색법대30례효천환자EBC중LTC4、8-ISO、NO-3진행검측,30례건강자작위대조.결과 효천환자적LTC4비대조조현저승고(55.17 ng/L비17.95 ng/L,P＜0.01),지속기비간헐기조현저승고(67.38 ng/L비41.21 ng/L,P＜0.01),지속기비대조조현저승고(67.38 ng/L비17.95 ng/L,P＜0.01),간헐기비대조조현저승고(41.21 ng/L비17.95 ng/L,P＜0.01),환자조비치료후조현저승고(55.17 ng/L비38.36 ng/L,P＜0.01).효천환자적8-ISO비대조조현저승고(13.41 ng/L비6.93 ng/L,P＜0.01),지속기조비대조조현저승고(14.29 ng/L비6.93 ng/L,P＜0.01),간헐기비대조조현저승고(12.40ng/L비6.93 ng/L,P＜0.05).효천환자적NO-3비대조조현저승고(4.17 ng/L비3.20 ng/L,P＜0.01),지속기조비대조조현저승고(4.50 ng/L비3.20 ng/L,P＜0.01).결론 LTC4、8 ISO、NO-3수평능구흔호적체현출효천환자적기도염증수평,이맹로사특약물능구흔호적공제기도염증수평,완해기도염증.
Objective To investigate the clinical significance of changes of leukotriene C4 (LTC4),8-isoprostane(8-ISO),nitrate levels in condensate of exhaled breath condensates (EBC) both before and after treatment in patients with asthma.Methods Enzymatic and colorimetric method of 30 cases of patients with asthma LTC4,8-in EBC ISO,nitrate for testing,30 cases are healthy control.Results LTC4 in patients with asthma is higher than the control group (55.17 ng/L than 17.95 ng/L,P ＜0.01),the persistent asthma is higher than Intermittent asthma (67.38 ng/L than 41.21 ng/L,P ＜0.01),the persistent asthma is higher than the control group (67.38 ng/L than 17.95 ng/L,P ＜0.01),the intermittent asthma is higher than the control group (41.21 ng/L than 17.95 ng/L,P ＜0.01),the untreated patients is higher than the treated group (55.17 ng/L than 38.36 ng/L,P ＜0.01).8-ISO in patients with asthma is higher than the control group(13.41 ng/L than 6.93 ng/L,P ＜0.01),the persistent asthma is higher than the control group to high (14.29 ng/L than 6.93 ng/L,P ＜0.01),the intermittent asthma is higher than the control group(12.40 ng/L than 6.93 ng/L,P ＜0.05).Nitrate in patients with asthma is higher than the control group (4.17 ng/L than 3.20 ng/L,P ＜0.01),the persistent asthma is higher than the control group (4.50 ng/L than 3.20 ng/L,P ＜0.01).Conclusions LTC4,8-1SO,nitrate levels can reflects the airway inflammation in patients with asthma and montelukast drugs can control and relieve the airway inflammation.
