CAJ | 학술논문

目的探讨慢性阻塞性肺疾病急性加重(AECOPD)患者气道限闭因素对症状恢复的影响.方法 2011年9月至2012年3月入院AECOPD患者80例,男58例,女22例,FEV1％pred＜50％,其中A组(FEV1 ％pred＜30％),B组(FEV1％pred 30％～50％)各40例.入院3d内行肺功能检查,测量FVC、FEV1,行呼吸困难分级评分(MMRC)、COPD评估表(CAT)评分,病程25～30 d时(恢复期)重复肺功能检查及评分.结果 A、B组△FVC/△FEV1分别为6.68±2.33、4.0±1.65(P＜0.01).A、B组恢复期MMRC及CAT评分明显下降(P＜0.05),△FVC/△FEV1与△MMRC、△CAT无明显相关(P＞0.05).结论 AECOPD恢复期,气道限闭改善与肺功能相关,肺功能更差组,△FVC/△FEV1值更大,小气道限闭及小气道功能改善更明显,但与呼吸困难症状、生活质量改善无明显相关.气道限闭及小气道功能的临床意义值得进一步研究.
목적 탐토만성조새성폐질병급성가중(AECOPD)환자기도한폐인소대증상회복적영향.방법 2011년9월지2012년3월입원AECOPD환자80례,남58례,녀22례,FEV1％pred＜50％,기중A조(FEV1 ％pred＜30％),B조(FEV1％pred 30％～50％)각40례.입원3d내행폐공능검사,측량FVC、FEV1,행호흡곤난분급평분(MMRC)、COPD평고표(CAT)평분,병정25～30 d시(회복기)중복폐공능검사급평분.결과 A、B조△FVC/△FEV1분별위6.68±2.33、4.0±1.65(P＜0.01).A、B조회복기MMRC급CAT평분명현하강(P＜0.05),△FVC/△FEV1여△MMRC、△CAT무명현상관(P＞0.05).결론 AECOPD회복기,기도한폐개선여폐공능상관,폐공능경차조,△FVC/△FEV1치경대,소기도한폐급소기도공능개선경명현,단여호흡곤난증상、생활질량개선무명현상관.기도한폐급소기도공능적림상의의치득진일보연구.
Objective To evaluate the contributions of airways closure on the improvement of symptom in patients with chronic obstructive pulmonary disease (COPD) during their recovering from an acute exacerbation.Methods Eighty patients with acute exacerbations of chronic obstructive disease (AECOPD) (male 58,female 22)were enrolled from Sep.2011 to Mar.2012,among them 40 with FEV1 ％pred＜30％(group A) and 40 with FEV1 ％pred 30％～50％(group B).Within the three days in hospital (day0),spirometric were checked,FEV1 and FVC (forced vital capacity) were measured,simutanusly.The scales including chronic obstructive pulmonary disease assessment test (CAT) and the measuring scales of dyspnea (MMRC) were completed.25-30days later (day25-30),The same asessments were added.Results During the recovering of an acute exacerbation,/△FVC/△FEV1 ＞ 1.The measurements of △FVC/△FEV1 in group A and group B were 6.68 ± 2.33 and 4.0 ± 1.65 respectively (P ＜0.01).The scores of CAT and MMRC declined obyiously (P ＜0.05).But neither △CAT or △MMRC has obvious relation with △FVC/△FEV1 (P ＞ 0.05).Conclusions During the recoverying of AECOPD,the improvement of the airway closure correlates with lung function.With the decline of lung function.The more improvement of airway closure and function of distal airways were seen,though having little relations with the△CAT and△MMRC.The clinical meanings of airway closure and function of distal airways in COPD deserve more investigations.