CAJ | 학술논문

针对RhoA及Rho激酶的研究揭示了其通路激活与肺血管病理生理改变相关,包括肺血管重塑如内膜功能失调、中膜平滑肌细胞增生及收缩舒张调节等.本文旨在回顾Rho激酶结构、调控通路及其介导肺血管重塑的病理生理学机制,归纳Rho激酶抑制剂治疗肺高血压的作用机制及其在动物模型和临床研究中的初步结果.
침대RhoA급Rho격매적연구게시료기통로격활여폐혈관병리생리개변상관,포괄폐혈관중소여내막공능실조、중막평활기세포증생급수축서장조절등.본문지재회고Rho격매결구、조공통로급기개도폐혈관중소적병리생이학궤제,귀납Rho격매억제제치료폐고혈압적작용궤제급기재동물모형화림상연구중적초보결과.
During the past few decades,studies have revealed the relationship between RhoA/Rhokinase signaling pathway and the pathophysiological process in pulmonary vascular diseases.The pathway has an intensive involvement in pulmonary vascular remodeling,including endothelial dysfunction,smooth muscle cell hypertrophy and proliferation.So the aim of this review is to introduce the structure of Rhokinase,how it regulates,and the pathophysiological mechanisms of Rho-kinase-mediated vascular remodeling.The underlying mechanisms of Rho-kinase inhibitor attenuating pulmonary hypertension (PH),as well as the therapeutic effect of Fasudil-a selective Rho-kinase inhibitor on PH animal model and patients are also discussed.