国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2013年
21期
1642-1646
,共5页
王碧瑛%林其昌%黄建钗%周金铃%谢汉生
王碧瑛%林其昌%黃建釵%週金鈴%謝漢生
왕벽영%림기창%황건차%주금령%사한생
睡眠呼吸暂停综合征%认知功能障碍%热休克蛋白70
睡眠呼吸暫停綜閤徵%認知功能障礙%熱休剋蛋白70
수면호흡잠정종합정%인지공능장애%열휴극단백70
Sleep apnea syndrome%Cognitive impairment%Heat shock proteins 70
目的 探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者认知功能障碍的严重程度与血清HSP70的相关性.方法 随机选择2012年1月至2012年12月在本院住院的行多导睡眠呼吸监测确诊的成人OSAHS患者41例作为病例组,并根据认知功能状况分为两组,即认知功能正常组、认知功能障碍组.同时随机选取同期44例健康体检者(免费PSG排除OSAHS)为正常对照组.用酶联免疫吸附法测定病例组、正常对照组血清中HSP70水平.结果 ①OSAHS病例组的血清HSP70水平明显高于正常对照组的血清HSP70水平,差异有统计学意义(P＜0.01).②认知功能障碍组的血清HSP70明显高于认知功能正常组的血清HSP70水平,差异有统计学意义(P＜0.01).③采用Pearson相关分析及线性回归分析显示,OSAHS患者认知功能障碍组血清HSP70水平和MoCA评分呈显著负相关(r=-0.680,P＜0.01),存在直线关系.结论 血清HSP70水平与OSAHS患者相关认知功能障碍发生存在相关性,且OSAHS患者的血清HSP70水平可能预计认知功能障碍的严重程度,可能成为其一个初步判断指标.P ＜0.05为差异具有统计学意义.
目的 探討阻塞性睡眠呼吸暫停低通氣綜閤徵(OSAHS)患者認知功能障礙的嚴重程度與血清HSP70的相關性.方法 隨機選擇2012年1月至2012年12月在本院住院的行多導睡眠呼吸鑑測確診的成人OSAHS患者41例作為病例組,併根據認知功能狀況分為兩組,即認知功能正常組、認知功能障礙組.同時隨機選取同期44例健康體檢者(免費PSG排除OSAHS)為正常對照組.用酶聯免疫吸附法測定病例組、正常對照組血清中HSP70水平.結果 ①OSAHS病例組的血清HSP70水平明顯高于正常對照組的血清HSP70水平,差異有統計學意義(P＜0.01).②認知功能障礙組的血清HSP70明顯高于認知功能正常組的血清HSP70水平,差異有統計學意義(P＜0.01).③採用Pearson相關分析及線性迴歸分析顯示,OSAHS患者認知功能障礙組血清HSP70水平和MoCA評分呈顯著負相關(r=-0.680,P＜0.01),存在直線關繫.結論 血清HSP70水平與OSAHS患者相關認知功能障礙髮生存在相關性,且OSAHS患者的血清HSP70水平可能預計認知功能障礙的嚴重程度,可能成為其一箇初步判斷指標.P ＜0.05為差異具有統計學意義.
목적 탐토조새성수면호흡잠정저통기종합정(OSAHS)환자인지공능장애적엄중정도여혈청HSP70적상관성.방법 수궤선택2012년1월지2012년12월재본원주원적행다도수면호흡감측학진적성인OSAHS환자41례작위병례조,병근거인지공능상황분위량조,즉인지공능정상조、인지공능장애조.동시수궤선취동기44례건강체검자(면비PSG배제OSAHS)위정상대조조.용매련면역흡부법측정병례조、정상대조조혈청중HSP70수평.결과 ①OSAHS병례조적혈청HSP70수평명현고우정상대조조적혈청HSP70수평,차이유통계학의의(P＜0.01).②인지공능장애조적혈청HSP70명현고우인지공능정상조적혈청HSP70수평,차이유통계학의의(P＜0.01).③채용Pearson상관분석급선성회귀분석현시,OSAHS환자인지공능장애조혈청HSP70수평화MoCA평분정현저부상관(r=-0.680,P＜0.01),존재직선관계.결론 혈청HSP70수평여OSAHS환자상관인지공능장애발생존재상관성,차OSAHS환자적혈청HSP70수평가능예계인지공능장애적엄중정도,가능성위기일개초보판단지표.P ＜0.05위차이구유통계학의의.
Objective To investigate the relationship between the level of heat shock proteins70 (HSP70) and the severity of cognitive impairment in adult patients with obstructive sleep apnea-hypopnea syndrome (OSAHS).Methods Forty newly diagnosed OSAHS patients by polysomnography were enrolled in our hospital from January 2012 to December 2012.The patients with OSAHS were divided into two groups according to Montreal Cognitive Assessment (MoCA):cognitively impaired group and not cognitively impaired group.Forty-four healthy subjects were randomly selected from medical center as normal control.The serum of HSP70 in the two groups were detected by ELISA.Results ① Serum HSP70 level in OSAHS group was significantly higher than that in normal control group(P ＜0.01).②The serum level of HSP70 in cognitively impaired group was significantly higher than that in normal cognitive function group(P ＜0.01).③The correlation analysis revealed that the serum HSP70 level was negatively correlated with the MoCA score in cognitively impaired patients with OSAHS.Conclusions The cognitive impairment in OSAHS patients is associated with the increased level of serum HSP70,HSP70 level may be used as a biochemical indicator for prognose cognitive impairment in OSAHS patients.
