国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2013年
23期
1770-1773
,共4页
朱峥%张云凤%邹盈%周春平%邱忠民
硃崢%張雲鳳%鄒盈%週春平%邱忠民
주쟁%장운봉%추영%주춘평%구충민
基质金属蛋白酶-9%基质金属蛋白酶组织抑制剂-1%白介素-8%慢性阻塞性肺疾病急性加重期%诱导痰%血清
基質金屬蛋白酶-9%基質金屬蛋白酶組織抑製劑-1%白介素-8%慢性阻塞性肺疾病急性加重期%誘導痰%血清
기질금속단백매-9%기질금속단백매조직억제제-1%백개소-8%만성조새성폐질병급성가중기%유도담%혈청
Matrix metalloproteinase-9%Tissue inhibitor of metalloproteinase-1%Interleukin-8%Acute exacerbation of chronic obstructive pulmonary disease%Induced sputum%Serum
目的 观察老年慢性阻塞性肺疾病急性加重期(AECOPD)患者治疗前后基质金属蛋白酶-9(MMP-9)、基质金属蛋白酶组织抑制剂1(TIMP-1)和白介素8(IL-8)浓度变化,探讨激素及β受体激动剂对治疗的影响.方法 入选40例AECOPD患者,随机分为4组,每组10例,分别给予常规、吸入激素、β受体激动剂和激素联合β受体激动剂等不同治疗,用ELISA分析检测各组血清和诱导痰中MMP-9、TIMP-1和IL-8的浓度.结果 激素联合β受体激动剂治疗组治疗后血清及诱导痰上清液MMP-9、TIMP-1和IL-8浓度下降具有统计学意义(P＜0.05).结论 激素联合β受体激动剂可能是拮抗COPD气道炎症和气道重塑的有效治疗手段.
目的 觀察老年慢性阻塞性肺疾病急性加重期(AECOPD)患者治療前後基質金屬蛋白酶-9(MMP-9)、基質金屬蛋白酶組織抑製劑1(TIMP-1)和白介素8(IL-8)濃度變化,探討激素及β受體激動劑對治療的影響.方法 入選40例AECOPD患者,隨機分為4組,每組10例,分彆給予常規、吸入激素、β受體激動劑和激素聯閤β受體激動劑等不同治療,用ELISA分析檢測各組血清和誘導痰中MMP-9、TIMP-1和IL-8的濃度.結果 激素聯閤β受體激動劑治療組治療後血清及誘導痰上清液MMP-9、TIMP-1和IL-8濃度下降具有統計學意義(P＜0.05).結論 激素聯閤β受體激動劑可能是拮抗COPD氣道炎癥和氣道重塑的有效治療手段.
목적 관찰노년만성조새성폐질병급성가중기(AECOPD)환자치료전후기질금속단백매-9(MMP-9)、기질금속단백매조직억제제1(TIMP-1)화백개소8(IL-8)농도변화,탐토격소급β수체격동제대치료적영향.방법 입선40례AECOPD환자,수궤분위4조,매조10례,분별급여상규、흡입격소、β수체격동제화격소연합β수체격동제등불동치료,용ELISA분석검측각조혈청화유도담중MMP-9、TIMP-1화IL-8적농도.결과 격소연합β수체격동제치료조치료후혈청급유도담상청액MMP-9、TIMP-1화IL-8농도하강구유통계학의의(P＜0.05).결론 격소연합β수체격동제가능시길항COPD기도염증화기도중소적유효치료수단.
Objective To observe the change of metalloproteinase (MMP)-9,tissue inhibitor of metalloproteinase (TIMP)-1 and interleukin(IL)-8 between pre-and post-treatment in elderly patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Furthermore,the effects of corticosteroid and β agonist were evaluated.Methods Forty patients with AECOPD were selected and randomly divided into four groups with 10 patients for each.Conventional treatment,inhaled corticosteroid,β3 agonist and inhaled corticosteroid combined with β3 agonist were respectively administered to the different groups.The levels of MMP-9,TIMP-1 and IL-8 in the induced sputum and serum of the patients from each group were detected by ELISA.Results In the group treated with corticosteroid plus β agonist,the levels of MMP-9,TIMP-1 and IL 8 in sputum and serum were lower in post-treatment than in prmtreatment.The difference showed a statistically significant decrease (P ＜ 0.05).Conclusions Corticosteroid combined with β agonist may be the effective therapy to inhibit airway inflammation and remodeling in COPD.
