CAJ | 학술논문

目的观察长期吸入布地奈德/福莫特罗联合体位引流预防支气管扩张再感染的临床疗效及生存质量的评价.方法 69例确诊为支气管扩张症的患者在经过急性期治疗、病情得到控制后,随机双盲对照方法,分为2组并进行12个月的维持治疗.对照组单纯体位引流,治疗组吸入布地奈德/福莫特罗的同时体位引流.观察患者的临床症状、呼吸困难评分、肺功能变化、急性发作频率及生存质量评分.结果有2例患者因大咯血行手术治疗退出本试验,有1例患者因呼吸衰竭退出本试验,66例完成研究.长期体位引流能够改善支气管扩张症患者的咳嗽咳痰的临床症状,但未能改善患者呼吸困难症状、肺功能、急性发作次数和生存质量,吸入布地奈德/福莫特罗与体位引流联合使用时,能够改善支气管扩张症患者的咳嗽咳痰的临床及呼吸困难症状,能减少急性发作次数,并可在一定程度上改善肺功能指标,提高患者生存质量.结论长期吸入糖皮质激素/β受体激动剂联合体位引流对支气管扩张症有较好的临床效果,可减轻患者的症状并减少急性发作次数,改善肺功能,提高患者生存质量,能够作为长期治疗支气管扩张症的一种选择.
목적 관찰장기흡입포지내덕/복막특라연합체위인류예방지기관확장재감염적림상료효급생존질량적평개.방법 69례학진위지기관확장증적환자재경과급성기치료、병정득도공제후,수궤쌍맹대조방법,분위2조병진행12개월적유지치료.대조조단순체위인류,치료조흡입포지내덕/복막특라적동시체위인류.관찰환자적림상증상、호흡곤난평분、폐공능변화、급성발작빈솔급생존질량평분.결과 유2례환자인대각혈행수술치료퇴출본시험,유1례환자인호흡쇠갈퇴출본시험,66례완성연구.장기체위인류능구개선지기관확장증환자적해수해담적림상증상,단미능개선환자호흡곤난증상、폐공능、급성발작차수화생존질량,흡입포지내덕/복막특라여체위인류연합사용시,능구개선지기관확장증환자적해수해담적림상급호흡곤난증상,능감소급성발작차수,병가재일정정도상개선폐공능지표,제고환자생존질량.결론 장기흡입당피질격소/β수체격동제연합체위인류대지기관확장증유교호적림상효과,가감경환자적증상병감소급성발작차수,개선폐공능,제고환자생존질량,능구작위장기치료지기관확장증적일충선택.
Objective To observe the long-term inhaled budesonide/formoterol combined with postural drainage in patients with bronehiectasis prevention bronchiectasis reinfection clinical curative effect and life quality evaluation.Methods Sixty-nine cases patients with bronchiectasis after exacerbation and maintained stable were randomly double-blind divided into two groups and 12 months of maintenance therapy.Control group simple postural drainage,treatment group inhaled budesonide/ formoterol,at the same time Postural drainage.Observation of patients with clinical symptoms,dyspnea scale,pulmonary function changes,acute seizure frequency and quality of life score.Results Two patients with big haemoptysis surgical treatment exit our test,one patient with respiratory failure exit our test,66 patients completed the study.The results showed that long-term position drainage can improve the clinical symptoms with bronchiectasis,whille failed to improve dyspnea in patients with symptoms,pulmonary function,the frequency of exacerbation and survival quality,inhalation budesonide/formoterol combined postural drainage can improve the clinical symptoms and dyspnea,can reduce the frequency of exacerbation in patients,and in a certain extent improve lung function index,and improve the patients quality of life.Conclusions Long term inhaled glucocorticoid/beta receptor agonist combined postural drainage to bronchiectasis had good clinical effect,can reduce the symptoms of patients and decrease the frequency of exacerbation in patients,improve lung function with bronchiectasis.It may be as an alternative to the maintenance treatment of bronchiectasis.