CAJ | 학술논문

支气管哮喘是一种慢性气道炎症性疾病,其病理生理特征主要表现为可逆性的气流受限和气道高反应性.其中嗜酸粒细胞、肥大细胞、中性粒细胞等是气道炎症的主要效应细胞.本文介绍了肥大细胞的来源、分型以及活化后释放的介质种类.重点综述了肥大细胞上Toll样受体的种类、作用以及在支气管哮喘的发生发展中的作用.
지기관효천시일충만성기도염증성질병,기병리생리특정주요표현위가역성적기류수한화기도고반응성.기중기산립세포、비대세포、중성립세포등시기도염증적주요효응세포.본문개소료비대세포적래원、분형이급활화후석방적개질충류.중점종술료비대세포상Toll양수체적충류、작용이급재지기관효천적발생발전중적작용.
Bronchial asthma (asthma) is a chronic inflammatory disease of the lower airways,characterized clinically by reversible airway obstruction and airway hyperresponsiveness (AHR).Eosinophils,mast cells and perhaps neutrophils are the major effector cells participated in the airways inflammation.In the present article,we have attempted to review the origin and subtypes of mast cells,as well as biological mediators released by activated mast cells.We focused on the types and roles of Tolllike receptors expressed by mast cells,which are potentially involved in the pathogenesis of bronchial asthma.