CAJ | 학술논문

黏着斑激酶(focal adhesion kinase,FAK)是一种胞质非受体蛋白酪氨酸激酶,在人、鸟、果蝇、鼠、非洲蟾蜍中均有表达并呈高度同源性.FAK在多器官和组织中均有表达,尤其是在肿瘤细胞中高水平表达.FAK介导的信号通路是细胞内各信号通路的交汇点,对正常细胞及肿瘤细胞黏附、迁移、增殖均起调控作用.在血管形成过程中,FAK可以通过FAK-Rho GTPases通路、FAK-PI3K通路等信号通路调节血管内皮细胞的黏附及迁移,调节细胞骨架重建.
점착반격매(focal adhesion kinase,FAK)시일충포질비수체단백락안산격매,재인、조、과승、서、비주섬서중균유표체병정고도동원성.FAK재다기관화조직중균유표체,우기시재종류세포중고수평표체.FAK개도적신호통로시세포내각신호통로적교회점,대정상세포급종류세포점부、천이、증식균기조공작용.재혈관형성과정중,FAK가이통과FAK-Rho GTPases통로、FAK-PI3K통로등신호통로조절혈관내피세포적점부급천이,조절세포골가중건.
Focal adhesion kinase (FAK) is a cytoplasmic non-receptor protein tyrosine kinase and has its expression in humans,birds,fruit flies,mice and xenopus with a high degree of homology.FAK has its expression as well in multiple organs and tissues,especially high expression in tumor cell.FAKmediated signal pathway is the intersection of all signal pathways,playing a regulatory role in the adhesion,migration and proliferation of both normal cells and the tumor cell.FAK can also through such signal pathways as FAK Rho GTPases pathway and FAK-PI3K pathway and etc.Regulate both the reconstruction of cytoskeleton and the adhesion and migration of vascular endothelial cells that is of great significance in that process.