CAJ | 학술논문

内皮祖细胞(endothelial progenitor cells,EPCs)是一组具备相似特征的异源性异质祖细胞.这些细胞具备以下两个基本特征:表达祖细胞相关标记和具备向成熟内皮细胞分化的能力.胎儿期EPCs参与血管系统的发育.出生后,EPCs来源于骨髓干细胞池,参与内皮修复和血管生成.骨髓中的EPCs经活化、募集进入外周血中.内源性及外源性EPCs具备归巢能力,即在特定生理条件下,EPCs定向迁移至特定部位,黏附及进入血管内皮层.EPCs与呼吸系统疾病密切相关.EPCs是与呼吸系统疾病密切相关的有效生物标志物;EPCs参与呼吸系统疾病的发病,也是呼吸疾病治疗的重要靶点;外源性EPCs还是呼吸系统疾病靶向基因治疗的潜在载体.
내피조세포(endothelial progenitor cells,EPCs)시일조구비상사특정적이원성이질조세포.저사세포구비이하량개기본특정:표체조세포상관표기화구비향성숙내피세포분화적능력.태인기EPCs삼여혈관계통적발육.출생후,EPCs래원우골수간세포지,삼여내피수복화혈관생성.골수중적EPCs경활화、모집진입외주혈중.내원성급외원성EPCs구비귀소능력,즉재특정생리조건하,EPCs정향천이지특정부위,점부급진입혈관내피층.EPCs여호흡계통질병밀절상관.EPCs시여호흡계통질병밀절상관적유효생물표지물;EPCs삼여호흡계통질병적발병,야시호흡질병치료적중요파점;외원성EPCs환시호흡계통질병파향기인치료적잠재재체.
Endothelial progenitor cells (EPCs) comprise rather heterogeneous cell sub-populations of multiple origins and localization,these cells were basically characterized by expression of progenitor markers and by terminal differentiation into mature endothelial cells.EPCs play a considerable role in vascular development during gestation.In adult,circulating EPCs are derived from stem cell niches in bone marrow,and contribute to endothelial repair and angiogenesis.Under special conditions,activated EPCs recruit in bone marrow EPCs and move out to the peripheral circulation.Homing ability is attributed to exogenous and endogenous EPCs that EPCs directed mobilize to specialized tissue site,adhesive to endothelium and enter into vascular endothelial layer.As an effective biomarker,EPCs may be utilized in respiratory diseases.For contributing to pathogenesis of multiple respiratory diseases,EPCs are a critical target for therapy.Exogenous EPCs are potential candidate vehicles for site-specific gene therapy.