CAJ | 학술논문

目的比较利奈唑胺与万古霉素治疗耐甲氧西林金黄色葡萄球菌(MRSA)所致呼吸机相关性肺炎的有效性及安全性.方法采取随机、对照的原则,选取重症监护病房确诊的MRSA所致呼吸机相关性肺炎患者62例.将入选患者随机分为2组,利奈唑胺组28例,每次600mg,每隔12小时1次,静脉滴注,治疗时间14 d;万古霉素组34例,每次1 000 mg,每隔12小时1次,静脉滴注,治疗时间14 d.观察2组患者的疗效和不良反应.结果利奈唑胺组有效率为78.57％,不良反应发生率为10.71％;万古霉素组有效率为52.94％,不良反应发生率为14.71％.2组临床有效率比较差异有统计学意义(P＜0.05),不良反应差异无统计学意义.结论利奈唑胺对MRSA引起的呼吸机相关性肺炎有较好的疗效.
목적 비교리내서알여만고매소치료내갑양서림금황색포도구균(MRSA)소치호흡궤상관성폐염적유효성급안전성.방법 채취수궤、대조적원칙,선취중증감호병방학진적MRSA소치호흡궤상관성폐염환자62례.장입선환자수궤분위2조,리내서알조28례,매차600mg,매격12소시1차,정맥적주,치료시간14 d;만고매소조34례,매차1 000 mg,매격12소시1차,정맥적주,치료시간14 d.관찰2조환자적료효화불량반응.결과 리내서알조유효솔위78.57％,불량반응발생솔위10.71％;만고매소조유효솔위52.94％,불량반응발생솔위14.71％.2조림상유효솔비교차이유통계학의의(P＜0.05),불량반응차이무통계학의의.결론 리내서알대MRSA인기적호흡궤상관성폐염유교호적료효.
Objective To compare the efficacy and safety of linezolid and vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) induced ventilator-associated pneumonia in intensive care unit.Methods In randomized controlled trials,62 patients with MRSA-induced ventilator-associated pneumonia in intensive care unit were randomly divided into two groups.Linezolid group (n =28) were administered with linezolid 600 mg every 12 hours for 14 days,ivgtt.Vancomycin group (n =34) were given vancomycin 1 000 mg every 12 hours for 14 days,ivgtt.Adverse events and the efficacy of two groups were investigated.Results The effective rates in linezolid group and vancomycin group were 78.57％ and 52.94％ (P ＜0.05).The adverse reaction rates in linezolid group and vancomycin group were 10.71％ and 14.71％.Conclusions Linezolid has positive effect in the treatment of MRSA induced ventilator-associated pneumonia.