国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2014年
9期
652-654
,共3页
慢性阻塞性肺疾病%幽门螺杆菌%白介素6%白介素17%肺功能
慢性阻塞性肺疾病%幽門螺桿菌%白介素6%白介素17%肺功能
만성조새성폐질병%유문라간균%백개소6%백개소17%폐공능
Chronic obstructive pulmonary disease%Helicobacter pylori%Interleukin-6%Interleukin-17%Lung function
目的 探讨幽门螺杆菌(Hp)感染与慢性阻塞性肺疾病(COPD)发病的相关性,分析COPD患者血清细胞因子IL-6、IL-17的变化,及与anti-Hp-IgG、肺功能FEV1％pred的相关性.方法 根据GOLD指南选取31例[男性20例,女性11例,平均年龄(62.74±4.27)岁]临床确诊的COPD稳定期患者为COPD组,同时选取性别、年龄相匹配的健康志愿者30例[男性18例,女性12例,平均年龄(61.97±3.16)岁]为对照组.采用ELISA方法检测anti-Hp-IgG、IL-6、IL-17的水平,并进行肺功能检测.结果 COPD组血清anti-Hp IgG水平明显高于对照组(P=0.042),且患者肺功能FEV1％pred与anti-Hp-IgG水平呈负相关(r=-0.662,P＜0.001);COPD组血清IL-6、IL-17水平分别明显高于对照组(P＜0.001,P=0.036),且IL-17水平与anti-HP-IgG水平呈正相关(r=0.671,P＜0.001)而与FEV1％ pred呈负相关(r=-0.615,P＜0.001).结论 Hp感染促进了COPD的进展,可能与炎性介质IL-17的激活有关.
目的 探討幽門螺桿菌(Hp)感染與慢性阻塞性肺疾病(COPD)髮病的相關性,分析COPD患者血清細胞因子IL-6、IL-17的變化,及與anti-Hp-IgG、肺功能FEV1％pred的相關性.方法 根據GOLD指南選取31例[男性20例,女性11例,平均年齡(62.74±4.27)歲]臨床確診的COPD穩定期患者為COPD組,同時選取性彆、年齡相匹配的健康誌願者30例[男性18例,女性12例,平均年齡(61.97±3.16)歲]為對照組.採用ELISA方法檢測anti-Hp-IgG、IL-6、IL-17的水平,併進行肺功能檢測.結果 COPD組血清anti-Hp IgG水平明顯高于對照組(P=0.042),且患者肺功能FEV1％pred與anti-Hp-IgG水平呈負相關(r=-0.662,P＜0.001);COPD組血清IL-6、IL-17水平分彆明顯高于對照組(P＜0.001,P=0.036),且IL-17水平與anti-HP-IgG水平呈正相關(r=0.671,P＜0.001)而與FEV1％ pred呈負相關(r=-0.615,P＜0.001).結論 Hp感染促進瞭COPD的進展,可能與炎性介質IL-17的激活有關.
목적 탐토유문라간균(Hp)감염여만성조새성폐질병(COPD)발병적상관성,분석COPD환자혈청세포인자IL-6、IL-17적변화,급여anti-Hp-IgG、폐공능FEV1％pred적상관성.방법 근거GOLD지남선취31례[남성20례,녀성11례,평균년령(62.74±4.27)세]림상학진적COPD은정기환자위COPD조,동시선취성별、년령상필배적건강지원자30례[남성18례,녀성12례,평균년령(61.97±3.16)세]위대조조.채용ELISA방법검측anti-Hp-IgG、IL-6、IL-17적수평,병진행폐공능검측.결과 COPD조혈청anti-Hp IgG수평명현고우대조조(P=0.042),차환자폐공능FEV1％pred여anti-Hp-IgG수평정부상관(r=-0.662,P＜0.001);COPD조혈청IL-6、IL-17수평분별명현고우대조조(P＜0.001,P=0.036),차IL-17수평여anti-HP-IgG수평정정상관(r=0.671,P＜0.001)이여FEV1％ pred정부상관(r=-0.615,P＜0.001).결론 Hp감염촉진료COPD적진전,가능여염성개질IL-17적격활유관.
Objective We aimed to investigate the level of anti-Hp-IgG,IL-6 and IL-17 in helicobacter pylori (Hp) patients with chronic obstructive pulmonary disease (COPD) to determine whether there is an association between Hp infection and COPD.Methods We evaluated 31 COPD patients [20 males and 11 females,aged (62.74 ± 4.27) years] and 30,age and sex-matched,control subjects.All subjects enrolled underwent an enzyme-linked immunosorbent assay (ELISA) test for antiHp-IgG,IL-6 and IL-17.We also test forced expiratory volume in 1 s (FEV1) values,which indicate the severity of COPD.Results Serum levels of Hp-specific IgG were significantly higher in the patients with COPD than in the control subjects (P =0.042).Inaddition,Hp serum IgG levels were correlated with FEV1 values(r =-0.662,P ＜0.001);Serum levels of IL-6 and IL-17 were significantly higher in the patients with COPD than in the control subjects (P ＜0.001,P =0.036,respectively).Moreover,serum IL-17 levels were correlated with FEV1 values(r =-0.615,P ＜0.001)and Hp serum IgG levels (r =0.671,P ＜0.001).Conclusions The results suggest that there is an association between Hp infection and COPD.Mybe the reason is associated to IL-17 actived.
