国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2014年
9期
655-658
,共4页
王美玲%曾奕明%陈晓阳%张祎祥
王美玲%曾奕明%陳曉暘%張祎祥
왕미령%증혁명%진효양%장의상
阻塞性睡眠呼吸暂停综合征%血脂%载脂蛋白A%载脂蛋白B
阻塞性睡眠呼吸暫停綜閤徵%血脂%載脂蛋白A%載脂蛋白B
조새성수면호흡잠정종합정%혈지%재지단백A%재지단백B
Obstructive sleep apnea syndrome%Lipid%Apolipoprotein A%Apolipoprotein B
目的 探讨非肥胖的阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome,OSAS)血清载脂蛋白B(apoB)/载脂蛋白A(apoA-I)比值的变化及可能的影响因素.方法 检测118例非肥胖OSAS患者及118例性别、年龄、体质量指数匹配健康对照组的血清apoA-I、apoB、甘油三酯、总胆固醇、高密度脂蛋白-胆固醇、低密度脂蛋白-胆固醇、肌酐、葡萄糖等生化指标,计算apoB/apoA-I比值,进行统计学处理及分析.结果 非肥胖OSAS患者的apoB/apoA-I比值(0.82±0.256)、apoB[(0.95±0.229) g/L]、甘油三酯[(1.53±0.912) mmol/L]较对照组[(0.70±0.200)、(0.88±0.202) g/L、(1.21±0.597) mmol/L]升高(t值分别为-3.921,-2.493,-3.242,P＜0.05);高密度脂蛋白-胆固醇[(1.09±0.301) mmol/L]低于对照组[(1.18±0.274) mmol/L],两组之间差异有统计学意义(t =2.609,P＜0.05).在控制了BMI的偏相关分析显示,apoB/apoA-I与睡眠呼吸暂停低通气指数呈正相关(偏相关系数=0.498,P＜0.05).结论 非肥胖OSAS患者存在血脂代谢异常,apoB/apoA-I比值与OSAS严重程度相关.
目的 探討非肥胖的阻塞性睡眠呼吸暫停綜閤徵(obstructive sleep apnea syndrome,OSAS)血清載脂蛋白B(apoB)/載脂蛋白A(apoA-I)比值的變化及可能的影響因素.方法 檢測118例非肥胖OSAS患者及118例性彆、年齡、體質量指數匹配健康對照組的血清apoA-I、apoB、甘油三酯、總膽固醇、高密度脂蛋白-膽固醇、低密度脂蛋白-膽固醇、肌酐、葡萄糖等生化指標,計算apoB/apoA-I比值,進行統計學處理及分析.結果 非肥胖OSAS患者的apoB/apoA-I比值(0.82±0.256)、apoB[(0.95±0.229) g/L]、甘油三酯[(1.53±0.912) mmol/L]較對照組[(0.70±0.200)、(0.88±0.202) g/L、(1.21±0.597) mmol/L]升高(t值分彆為-3.921,-2.493,-3.242,P＜0.05);高密度脂蛋白-膽固醇[(1.09±0.301) mmol/L]低于對照組[(1.18±0.274) mmol/L],兩組之間差異有統計學意義(t =2.609,P＜0.05).在控製瞭BMI的偏相關分析顯示,apoB/apoA-I與睡眠呼吸暫停低通氣指數呈正相關(偏相關繫數=0.498,P＜0.05).結論 非肥胖OSAS患者存在血脂代謝異常,apoB/apoA-I比值與OSAS嚴重程度相關.
목적 탐토비비반적조새성수면호흡잠정종합정(obstructive sleep apnea syndrome,OSAS)혈청재지단백B(apoB)/재지단백A(apoA-I)비치적변화급가능적영향인소.방법 검측118례비비반OSAS환자급118례성별、년령、체질량지수필배건강대조조적혈청apoA-I、apoB、감유삼지、총담고순、고밀도지단백-담고순、저밀도지단백-담고순、기항、포도당등생화지표,계산apoB/apoA-I비치,진행통계학처리급분석.결과 비비반OSAS환자적apoB/apoA-I비치(0.82±0.256)、apoB[(0.95±0.229) g/L]、감유삼지[(1.53±0.912) mmol/L]교대조조[(0.70±0.200)、(0.88±0.202) g/L、(1.21±0.597) mmol/L]승고(t치분별위-3.921,-2.493,-3.242,P＜0.05);고밀도지단백-담고순[(1.09±0.301) mmol/L]저우대조조[(1.18±0.274) mmol/L],량조지간차이유통계학의의(t =2.609,P＜0.05).재공제료BMI적편상관분석현시,apoB/apoA-I여수면호흡잠정저통기지수정정상관(편상관계수=0.498,P＜0.05).결론 비비반OSAS환자존재혈지대사이상,apoB/apoA-I비치여OSAS엄중정도상관.
Objective The aim of this study was to investigate the apoB/apoA-I ratio in nonobese patients with obstructive sleep apnea syndrome (OSAS).Methods One hundred and eighteen nonobese patients with OSAS and 118 age,gender and BMI matched healthy individuals without signs and symptoms of apnea-hypopnea received biochemistry analysis.Results In nonobese OSAS group,the apoB/apoA-I ratio (0.82 ± 0.256),apoB[(0.95 ± 0.229) g/L],TG [(1.53 ± 0.912) mmol/L] were higher than control group[(0.70±0.200),(0.88±0.202) g/L,(1.21±0.597) mmol/L](t =-3.921,-2.493,-3.242,P ＜0.05),and HDL-C[(1.09 ± 0.301) mmol/L] were lower compared with control group [(1.18±0.274) mmol/L](t =2.609,P ＜0.05).After controlling for BMI,the apoB/apoA-I ratio was correlated with AHI (partial correlation coefficient =0.498,P ＜ 0.05).Conclusions OSAS can induce lipid metabolism disorder in nonobese patients and the apoB/apoA-I ratio was correlated with severity of OSAS.
