CAJ | 학술논문

在黏膜免疫系统中,M细胞扮演着摄取抗原、然后将抗原传递给其下游的淋巴组织的重要角色,起到开启免疫应答的作用.M细胞的分化来源、结构特点和摄取抗原的机制等对于体外诱导培养M细胞,探索黏膜免疫机制,完善靶向于M细胞的黏膜疫苗及口服药物设计等具有重要意义.近几年有关M细胞的分化来源,调节其分化及转运的因子,以及其特异表面分子和转运机制等方面的研究已有了较大的进展.
재점막면역계통중,M세포분연착섭취항원、연후장항원전체급기하유적림파조직적중요각색,기도개계면역응답적작용.M세포적분화래원、결구특점화섭취항원적궤제등대우체외유도배양M세포,탐색점막면역궤제,완선파향우M세포적점막역묘급구복약물설계등구유중요의의.근궤년유관M세포적분화래원,조절기분화급전운적인자,이급기특이표면분자화전운궤제등방면적연구이유료교대적진전.
In the mucosal immune system,M cell plays an important role which uptakes and transports antigen to the underlying mucosal lymphoid tissue for initiating immune responses.Therefore,the origin,the characters of structure and morphology,and the antigen sampling mechanism of M cell are significant for culturing and inducing M cell in vitro,exploring the mechanism of mucosal immunity,designing the targeted mucosal vaccine as well as targeted oral drugs.In recent years,the research about the origin,the factors about regulating differentiation and transportation,the special surface molecules as well as the transportation mechanism of M cell has made great progress.