CAJ | 학술논문

弓形虫棒状体颈部蛋白(rhoptry neck proteins,RONs)是由棒状体分泌的,构成运动结合体(moving junction,MJ)不可或缺的一部分,由于MJ在虫体入侵宿主细胞过程中起至关重要的作用,因此,对于RONs蛋白的研究,有助于更好地了解刚地弓形虫的致病机制,探寻预防和治疗弓形虫病的有效方法.该文就弓形虫棒状体颈部蛋白的结构和功能加以综述,并对该领域今后可能的研究方向进行展望,以期从棒状体颈部蛋白角度对弓形虫研究提供新的思路.
궁형충봉상체경부단백(rhoptry neck proteins,RONs)시유봉상체분비적,구성운동결합체(moving junction,MJ)불가혹결적일부분,유우MJ재충체입침숙주세포과정중기지관중요적작용,인차,대우RONs단백적연구,유조우경호지료해강지궁형충적치병궤제,탐심예방화치료궁형충병적유효방법.해문취궁형충봉상체경부단백적결구화공능가이종술,병대해영역금후가능적연구방향진행전망,이기종봉상체경부단백각도대궁형충연구제공신적사로.
In Toxoplasma gondii,rhoptry neck proteins(RONs) are secreted by rhoptry for the formation of moving junction (MJ),which plays an important role in the invasion of T.gondii.Therefore,the research on RONs can help us to better understand the pathogenic mechanism of T.gondii and explore the effective approaches for prevention and treatment of toxoplasmosis.In this paper,the structure and function of RONs are summarized and the probable research directions in this field in the future are discussed,in order to provide new aspects of the T.gondii study for the researches.