CAJ | 학술논문

疟原虫入侵宿主肝细胞并在其中发育增殖是建立疟疾感染的关键环节,因此该阶段也成为抗疟药物和疫苗研发针对的重要靶标.肝期原虫的入侵和发育涉及多种宿主肝细胞来源分子与疟原虫来源分子的相互作用.近年来的研究陆续发现了一些疟原虫与宿主相互作用中发挥重要功能的宿主肝细胞来源分子.该文就影响子孢子入侵、疟原虫肝细胞内生长发育和营养代谢、宿主对疟原虫免疫反应的肝细胞来源分子研究进展进行综述.
학원충입침숙주간세포병재기중발육증식시건립학질감염적관건배절,인차해계단야성위항학약물화역묘연발침대적중요파표.간기원충적입침화발육섭급다충숙주간세포래원분자여학원충래원분자적상호작용.근년래적연구륙속발현료일사학원충여숙주상호작용중발휘중요공능적숙주간세포래원분자.해문취영향자포자입침、학원충간세포내생장발육화영양대사、숙주대학원충면역반응적간세포래원분자연구진전진행종술.
The development and proliferation of liver-stage Plasmodium are the key steps of Plasmodium infection,and represent an attractive target for anti-malarial drug and vaccine development.The development of liver-stage Plasmodium involves the molecular mechanism of interaction between parasites and host liver cells.In recent years,researches have identified some important molecules derived from host liver cell involved in host-parasite interaction.This article reviews the research progress on host hepatocyte molecules involved in sporozoite invasion,growth,metabolism and host immunoreaction.