CAJ | 학술논문

目的研究中国人群ABO血型与疟疾易感性之间的关系. 方法通过查询重庆维普、Medline数据库收集国内外1980年1月1日至2013年3月1日之间公开发表的关于ABO血型与疟疾易感性的中英文文献资料,采用荟萃分析软件RevMan 5进行Meta分析. 结果 7篇文献被纳入到本次分析.Meta分析结果显示,A型血与非A型血人群相比,疟疾的发病风险合并相对危险度(RR)及(95％CI)为1.27(1.03～1.57);B型血与非B型血人群相比,为0.97(0.80～1.17);AB型血与非AB型血人群相比,为0.92(0.80～1.06);O型血与非O型血人群相比,为0.80(0.73 ～ 0.88).各亚组研究通过Egger回归法进行发表性偏倚分析,P值分别为0.32、0.87、0.30、0.72,均＞0.10. 结论各亚组研究可认为无发表性偏倚,对于中国人群,A型血较之其他血型对疟疾多27％的感染可能,而O型血较之其他血型少20％的感染可能.
목적 연구중국인군ABO혈형여학질역감성지간적관계. 방법 통과사순중경유보、Medline수거고수집국내외1980년1월1일지2013년3월1일지간공개발표적관우ABO혈형여학질역감성적중영문문헌자료,채용회췌분석연건RevMan 5진행Meta분석. 결과 7편문헌피납입도본차분석.Meta분석결과현시,A형혈여비A형혈인군상비,학질적발병풍험합병상대위험도(RR)급(95％CI)위1.27(1.03～1.57);B형혈여비B형혈인군상비,위0.97(0.80～1.17);AB형혈여비AB형혈인군상비,위0.92(0.80～1.06);O형혈여비O형혈인군상비,위0.80(0.73 ～ 0.88).각아조연구통과Egger회귀법진행발표성편의분석,P치분별위0.32、0.87、0.30、0.72,균＞0.10. 결론 각아조연구가인위무발표성편의,대우중국인군,A형혈교지기타혈형대학질다27％적감염가능,이O형혈교지기타혈형소20％적감염가능.
Objective To explore the relationship between ABO blood groups and malaria among Chinese population.Methods The articles published from 1th January,1980 to 1th March,2013 from Chongqing VIP Information and Medline database on the relationship between ABO blood groups and malaria risk were searched.RevMan 5 was used for meta-analysis.Results Seven articles were involved in our study.Compared with non-A groups,the RR (95％CI) of malaria in individuals with blood group A was 1.27(1.03-1.57); compared with non-B groups,the RR (95％CI) of malaria in individuals with blood group B was 0.97 (0.80-1.17); compared with non-AB groups,the RR (95％CI) of malaria in individuals with blood group AB was 0.92 (0.80-1.06); compared with non-O groups,the RR (95％CI) of malaria in individuals with blood group O was 0.80 (0.73-0.88).Publication bias of each subgroup study was conducted by the method of Egger regression analysis,the P valued were 0.32,0.87,0.30,0.72,respectively,which were greater than the inspection level of 0.10.Conclusion As there was no publication bias in each subgroup study,the results of the Meta-analysis implied that,for the Chinese population,people with blood group A is 27％ more susceptible to malaria than other blood groups,while blood group O is 20％ less susceptible.