CAJ | 학술논문

目的探讨昆明地区2011年住院手足口病(HFMD)患儿的临床及病原学特点,为临床诊断提供依据.方法对2011年1至12月1449例住院患者的临床表现、病原学、流行病学、治疗方法及转归进行回顾性分析.结果 HFMD发病主要集中于4～7月,男女性别比为1.27∶1,发病年龄主要集中在5岁以下(92.62％).对其中1400例患儿的粪便行荧光定量RT-PCR核酸检测:检出病原1018例(72.71％),其中EV71阳性915例(89.88％),CoxA16阳性103例(10.11％).1449例住院患儿中重症病例1186例(81.85％),治疗结果为3例死亡,2例好转,其余1444例痊愈出院.结论昆明地区2011年HFMD发病高峰期为4～7月,以5岁以下儿童为主体,引起死亡和重症的病原体为EV71.早期诊断和合理治疗是最大程度降低HFMD死亡率、致残率的关键.
목적 탐토곤명지구2011년주원수족구병(HFMD)환인적림상급병원학특점,위림상진단제공의거.방법 대2011년1지12월1449례주원환자적림상표현、병원학、류행병학、치료방법급전귀진행회고성분석.결과 HFMD발병주요집중우4～7월,남녀성별비위1.27∶1,발병년령주요집중재5세이하(92.62％).대기중1400례환인적분편행형광정량RT-PCR핵산검측:검출병원1018례(72.71％),기중EV71양성915례(89.88％),CoxA16양성103례(10.11％).1449례주원환인중중증병례1186례(81.85％),치료결과위3례사망,2례호전,기여1444례전유출원.결론 곤명지구2011년HFMD발병고봉기위4～7월,이5세이하인동위주체,인기사망화중증적병원체위EV71.조기진단화합리치료시최대정도강저HFMD사망솔、치잔솔적관건.
Objective To explore the clinical and pathogenic characteristics of children with hand,foot and mouth disease(HFMD)of Kunming area in 2011 and offer more evidence for clinical diagnosis.Methods The clinical features,etiology,epidemiology,treatment and outcome of 1449 hospitalized patents with HFMD were analyzed retrospectively.Results Peak infection months of HFMD was from April to July.The sex ratio of male to female patients was 1.27∶1.Most of the patients (92.62％) were under five years old.The feces of 1400 patients were detected by fluorescence quantitative RT-PCR.The results showed that 1018 cases were pathogen poeitive (72.71％),915 cases (89.88％) were EV71 positive,103 cases (10.11％) were CoxA16 positive.There were 1186 severe cases (81.85％)in 1449 inpatients.Three cases died,2 cases improved,the other 1444 cases were cured.Conclusions Peak months of HFMD in Kunming area in 2011 is from April to July.Most cases are under the age of five.The main pathogen which can cause severe HFMD and death is EV 71.Early diagnosis and treatment are important to reduce disabled rate and mortality of HFMD.