CAJ | 학술논문

目的分析浙江省温州地区感染肠道病毒71型(EV71)死亡病例的临床特征.方法回顾性分析温州医学院附属育英儿童医院23例EV71感染死亡病例的临床特点、发病过程及实验室特征.结果 23例患儿平均年龄18.6月龄(4月龄～4岁),3周岁以下患儿19例；典型皮疹11例.16例心肺衰竭期死亡患儿入院时小儿危重病例评分(PCIS)为(50.6±4.7)分,其中11例于病情加重后24h内死亡,直接死因主要为循环功能衰竭和难治性休克.7例恢复期死亡患儿入院时PCIS为(52.3±6.3)分,除1例机械通气247d死于肺部感染外,其他6例均在进入恢复期后5.5(4～7)d死于脑干脑炎后呼吸中枢抑制.结论死亡患儿病程进展急促,多于急性期死亡.进入恢复期患儿,如存在呼吸机依赖,仍无法存活.
목적 분석절강성온주지구감염장도병독71형(EV71)사망병례적림상특정.방법 회고성분석온주의학원부속육영인동의원23례EV71감염사망병례적림상특점、발병과정급실험실특정.결과 23례환인평균년령18.6월령(4월령～4세),3주세이하환인19례；전형피진11례.16례심폐쇠갈기사망환인입원시소인위중병례평분(PCIS)위(50.6±4.7)분,기중11례우병정가중후24h내사망,직접사인주요위순배공능쇠갈화난치성휴극.7례회복기사망환인입원시PCIS위(52.3±6.3)분,제1례궤계통기247d사우폐부감염외,기타6례균재진입회복기후5.5(4～7)d사우뇌간뇌염후호흡중추억제.결론 사망환인병정진전급촉,다우급성기사망.진입회복기환인,여존재호흡궤의뢰,잉무법존활.
Objective To analysis the clinical characteristics of 23 death cases of enterovirus 71 (EV71) infection in Wenzhou City Zhejiang Province.Methods The clinical characteristics,disease course and laboratory features of 23 death cases of EV71 infection in Yuying Children's Hospital Affiliated to Wenzhou Medical University.Results The average age of those children were 18.6 months(4 months-4 years old),among them 19 cases were younger than 3 years old,and there were typical rash in 11 cases.Sixteen cases with an average pediatric critical illness score(PCIS) of (50.6± 4.7) died in stage of heart and lung exhaustion,including 11 cases who died within 24 hours because of aggravation,the main causes of death were circulation failure and refractory shock.The PCIS score of 7 cases was (52.3±6.3) on admission who died in recovery period,1 case died of pulmonary infection in the 247th day after mechanical ventilation,the other 6 cases died in the first 5.5 (4-7) days because of respiratory center inhibition after brainstem encephalitis.Conclusions Most of the death cases of EV71 infection showed rapid process and died in the acute stage.If children in recovery phase relies on breathing machine,they still cannot survive.