CAJ | 학술논문

细菌的耐药性一直是细菌感染性疾病治疗的最大障碍.除了基因突变产生的耐药外,还存在一种难以被常规或高浓度的药物杀灭,但耐药性没有遗传的数量极少的耐药亚群.这一亚群在抗生素压力降低后,部分细菌又可以繁殖再生,同时对之前的抗生素保持敏感,并与被杀灭的细菌保持同源性,这些细菌就被称为持留菌.此文就持留菌的形成机制、种类、清除方法及其与耐药菌的关系等最新的研究进展进行了综述.
세균적내약성일직시세균감염성질병치료적최대장애.제료기인돌변산생적내약외,환존재일충난이피상규혹고농도적약물살멸,단내약성몰유유전적수량겁소적내약아군.저일아군재항생소압력강저후,부분세균우가이번식재생,동시대지전적항생소보지민감,병여피살멸적세균보지동원성,저사세균취피칭위지류균.차문취지류균적형성궤제、충류、청제방법급기여내약균적관계등최신적연구진전진행료종술.
Bacteria resistance is the biggest obstacle of bacterial infectious disease treatment.Despite some drug resistant bacteria produced by genetic mutation,there is a small amount of multidrug-tolerant subgroup which is hardly killed by antibiotic at normal or high concentration,and keeps no genetic resistance.When the antibiotic concentration reduced,some bacteria of this subgroup can reproduce,and remain sensitive to prior antibiotic at the same time,and keep homology with the other killed bacteria of this subgroup,these bacteria are called persisters.In this article,the htest research processes about the formation mechanism,different types,elimination methods of persisters and its relationship with drug resistance bacteria are reviewed.