国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2014年
1期
11-16
,共6页
乳头状瘤病毒感染%L1壳蛋白%宫颈病变%宫颈癌%Meta分析
乳頭狀瘤病毒感染%L1殼蛋白%宮頸病變%宮頸癌%Meta分析
유두상류병독감염%L1각단백%궁경병변%궁경암%Meta분석
Papillomavirus infections%L1 capsid protein%Cervical lesions%Cervical cancer%Meta-analysis
目的 探讨HPV L1壳蛋白与宫颈病变关系.方法 检索国内外相关文献,应用RevMan5.2软件对HPV L1壳蛋白与宫颈病变分级和宫颈病变预后的关系进行Meta分析,以OR值和95％CI为效应尺度.结果 在HPV L1壳蛋白表达与宫颈病变分级关系的研究中共纳入14篇文献,宫颈上皮内瘤变(CIN)Ⅰ组与CINⅡ组、CINⅡ组与CINⅢ组、CINⅢ组与鳞状细胞癌(SCC)组的HPV L1壳蛋白阳性率的比较合并OR值分别为:3.83(95％CI:3.00～4.88)、3.01 (95％CI:1.85～4.89)和4.44(95％CI:2.09～9.43)；在HPV L1壳蛋白表达与宫颈病变进展关系的研究中,共纳入4篇文献,HPV L1壳蛋白阴性组与阳性组在各种宫颈病变结局中的比较中发现,病变消退、病变稳定、病变进展3个亚组中的OR值分别为0.20 (95％CI:0.06～0.64,P＜0.05)、1.11 (95％CI:0.78～1.58,P＞0.05)和4.68 (95％CI:2.55～8.56,P＜0.01).结论 HPV L1壳蛋白的表达与宫颈病变的分级密切相关,宫颈病变中HPV L1壳蛋白表达情况可提供预后和转归的信息,HPV L1壳蛋白阳性的患者其病变更易消退,而阴性者其病变更易进展到高级别CIN甚至SCC.
目的 探討HPV L1殼蛋白與宮頸病變關繫.方法 檢索國內外相關文獻,應用RevMan5.2軟件對HPV L1殼蛋白與宮頸病變分級和宮頸病變預後的關繫進行Meta分析,以OR值和95％CI為效應呎度.結果 在HPV L1殼蛋白錶達與宮頸病變分級關繫的研究中共納入14篇文獻,宮頸上皮內瘤變(CIN)Ⅰ組與CINⅡ組、CINⅡ組與CINⅢ組、CINⅢ組與鱗狀細胞癌(SCC)組的HPV L1殼蛋白暘性率的比較閤併OR值分彆為:3.83(95％CI:3.00～4.88)、3.01 (95％CI:1.85～4.89)和4.44(95％CI:2.09～9.43)；在HPV L1殼蛋白錶達與宮頸病變進展關繫的研究中,共納入4篇文獻,HPV L1殼蛋白陰性組與暘性組在各種宮頸病變結跼中的比較中髮現,病變消退、病變穩定、病變進展3箇亞組中的OR值分彆為0.20 (95％CI:0.06～0.64,P＜0.05)、1.11 (95％CI:0.78～1.58,P＞0.05)和4.68 (95％CI:2.55～8.56,P＜0.01).結論 HPV L1殼蛋白的錶達與宮頸病變的分級密切相關,宮頸病變中HPV L1殼蛋白錶達情況可提供預後和轉歸的信息,HPV L1殼蛋白暘性的患者其病變更易消退,而陰性者其病變更易進展到高級彆CIN甚至SCC.
목적 탐토HPV L1각단백여궁경병변관계.방법 검색국내외상관문헌,응용RevMan5.2연건대HPV L1각단백여궁경병변분급화궁경병변예후적관계진행Meta분석,이OR치화95％CI위효응척도.결과 재HPV L1각단백표체여궁경병변분급관계적연구중공납입14편문헌,궁경상피내류변(CIN)Ⅰ조여CINⅡ조、CINⅡ조여CINⅢ조、CINⅢ조여린상세포암(SCC)조적HPV L1각단백양성솔적비교합병OR치분별위:3.83(95％CI:3.00～4.88)、3.01 (95％CI:1.85～4.89)화4.44(95％CI:2.09～9.43)；재HPV L1각단백표체여궁경병변진전관계적연구중,공납입4편문헌,HPV L1각단백음성조여양성조재각충궁경병변결국중적비교중발현,병변소퇴、병변은정、병변진전3개아조중적OR치분별위0.20 (95％CI:0.06～0.64,P＜0.05)、1.11 (95％CI:0.78～1.58,P＞0.05)화4.68 (95％CI:2.55～8.56,P＜0.01).결론 HPV L1각단백적표체여궁경병변적분급밀절상관,궁경병변중HPV L1각단백표체정황가제공예후화전귀적신식,HPV L1각단백양성적환자기병변경역소퇴,이음성자기병변경역진전도고급별CIN심지SCC.
Objective To investigate the relationship between human papillomavirus(HPV) L1 capsid protein and cervical lesions.Methods A meta-analysis of published data was performed to analyze the correlation of HPV L1 capsid protein expression with cervical lesion classification and prognosis by RevMan5.2 software.The effects of these outcomes were measured by OR and 95％CI.Results Fourteen reports were included to analyze the relationship between HPV L1 capsid protein and cervical lesion classification.The pooled OR with 95％CI of cervical intraepithelial neoplasia(CIN) Ⅰ vs CIN Ⅱ,CIN Ⅱ vs CINⅢ,CIN Ⅲvs squamous cell carcinoma(SCC) were 3.83 (95％CI:3.00-4.88),3.01 (95％CI:1.85-4.89) and 4.44(95％CI:2.09-9.43) in HPV L1 capsid protein expression,respectively.Four reports were included to analyze the relationship between HPV L1 capsid protein and the development of cervical lesions.The OR with 95％CI of HPV L1 capsid protein negative vs positive in 3 subgroups of lesion regression,lesion stable and lesion deterioration were 0.20 (95％CI:0.06-0.64,P＜0.05),1.1 1 (95％CI:0.78-1.58,P＞0.05) and 4.68 (95％CI:2.55-8.56,P＜0.01) respectively.Conclusions The expression of HPV L1 capsid protein is closely related to cervical lesions progression,and may be associated with the prognosis and outcome of cervical lesions.The patients with HPV L1 capsid protein positive are more likely to get improved,while the negative ones are more likely to develop to higher grade CIN,even SCC.
