国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2014年
2期
101-103
,共3页
梅毒%妊娠%早期干预%妊娠结局
梅毒%妊娠%早期榦預%妊娠結跼
매독%임신%조기간예%임신결국
Syphilis%Pregnancy%Early intervention%Pregnant outcome
目的 探讨妊娠期梅毒早期规范化治疗对围产儿预后的影响.方法 对浙江省天台县人民医院51例产前筛查确诊并经规范抗梅毒治疗的妊娠梅毒孕妇的妊娠结局进行回顾性分析,选择同期住院分娩的11例未规范化治疗的妊娠期梅毒病例进行对照.结果 妊娠期梅毒早期规范化治疗孕妇共分娩新生儿51例,其中足月产50例,早产1例,无流产、死胎发生.新生儿血清梅毒螺旋体颗粒凝集试验(TPPA)阳性、快速血浆反应素环状卡片试验(RPR)阴性21例,TPPA、RPR均阳性(滴度≤1∶8)11例,经1～6个月随访均自行转阴.妊娠期梅毒未规范化治疗的孕妇发生死胎、新生儿死亡和足月梅毒儿共9例(81.82％).外地孕妇不良妊娠发生率为30.43％(7/23),明显高于本地孕妇的7.69％(3/39);无固定职业孕妇不良结局发生率为24.32％(9/37),高于有固定职业孕妇的4.00％(1/25),两组差异均有统计学意义(x2=5.53、4.55,P＜0.05).结论 妊娠梅毒早期规范化治疗能够有效改善妊娠结局,提高流动人口、无固定职业孕妇的建卡率,能有效避免妊娠梅毒不良结局的发生.
目的 探討妊娠期梅毒早期規範化治療對圍產兒預後的影響.方法 對浙江省天檯縣人民醫院51例產前篩查確診併經規範抗梅毒治療的妊娠梅毒孕婦的妊娠結跼進行迴顧性分析,選擇同期住院分娩的11例未規範化治療的妊娠期梅毒病例進行對照.結果 妊娠期梅毒早期規範化治療孕婦共分娩新生兒51例,其中足月產50例,早產1例,無流產、死胎髮生.新生兒血清梅毒螺鏇體顆粒凝集試驗(TPPA)暘性、快速血漿反應素環狀卡片試驗(RPR)陰性21例,TPPA、RPR均暘性(滴度≤1∶8)11例,經1～6箇月隨訪均自行轉陰.妊娠期梅毒未規範化治療的孕婦髮生死胎、新生兒死亡和足月梅毒兒共9例(81.82％).外地孕婦不良妊娠髮生率為30.43％(7/23),明顯高于本地孕婦的7.69％(3/39);無固定職業孕婦不良結跼髮生率為24.32％(9/37),高于有固定職業孕婦的4.00％(1/25),兩組差異均有統計學意義(x2=5.53、4.55,P＜0.05).結論 妊娠梅毒早期規範化治療能夠有效改善妊娠結跼,提高流動人口、無固定職業孕婦的建卡率,能有效避免妊娠梅毒不良結跼的髮生.
목적 탐토임신기매독조기규범화치료대위산인예후적영향.방법 대절강성천태현인민의원51례산전사사학진병경규범항매독치료적임신매독잉부적임신결국진행회고성분석,선택동기주원분면적11례미규범화치료적임신기매독병례진행대조.결과 임신기매독조기규범화치료잉부공분면신생인51례,기중족월산50례,조산1례,무유산、사태발생.신생인혈청매독라선체과립응집시험(TPPA)양성、쾌속혈장반응소배상잡편시험(RPR)음성21례,TPPA、RPR균양성(적도≤1∶8)11례,경1～6개월수방균자행전음.임신기매독미규범화치료적잉부발생사태、신생인사망화족월매독인공9례(81.82％).외지잉부불량임신발생솔위30.43％(7/23),명현고우본지잉부적7.69％(3/39);무고정직업잉부불량결국발생솔위24.32％(9/37),고우유고정직업잉부적4.00％(1/25),량조차이균유통계학의의(x2=5.53、4.55,P＜0.05).결론 임신매독조기규범화치료능구유효개선임신결국,제고류동인구、무고정직업잉부적건잡솔,능유효피면임신매독불량결국적발생.
Objective To explore the impact of standardized treatment of syphilis in early pregnancy on perinatal infantile outcome.Methods The clinical data of 51 patients with pregnancy complicated by syphilis who received standardized protocol for treatment of syphilis were retrospectively analyzed.They were diagnosed as having syphilis when they had routine prenatal examination at 12 weeks of pregnancy and received the corresponding treatment immediately.Eleven pregnant patients with syphilis who did not receive any intervention were selected as controls.Results Fifty-one patients with early intervention gave birth to 51 neonates,among which 50 were fullterm births and the rest one was preterm infant; no abortion and dead fetus occurred.Serum treponema palidum particle agglutination test (TPPA) was detected positive and rapid plasma regain test (RPR) was detected negative in 21 neonates; both of TPPA and RPR were detected positive (titers≤l∶8) in 11 neonates; the positive index were all found conversion to negative after 1-6 month follow-up.Of 1 1 controls,9 (81.82％) had stillbirth,neonatal death,or congenital syphilis.The incidence of adverse pregnant outcomes in floating pregnancy was 30.43％ (7/23),which was significantly higher than that of local pregnant women [7.69％ (3/39),x2=5.53,P＜0.05]; the rate in cases who did not have any regular job was 24.32％ (9/37),which was significantly higher than that in cases who had regular ones [4.00％(1/25),x2=4.55,P＜0.05].Conclusions The treatment of syphilis in early pregnancy can improve the outcome of pregnancy.To strengthen the follow-up of pregnant women,especially those in floating population,can avoid adverse outcomes of pregnancy complicated by syphilis.
