CAJ | 학술논문

目的系统评价抗结核药莫西沙星与肺结核痰转化率(SCR)的相关性.方法检索中国知网(CNKI)、维普中文科技期刊全文数据库和万方数据库等中文数据库以及美国国立图书馆(PubMed)、荷兰医学文摘(EMBASE)和Cochrane图书馆等英文数据库,运用Meta分析方法综合评价莫西沙星与肺结核SCR的相关性.文献资料使用RevMan4.2软件进行Meta分析.结果共纳入7篇研究,包含治疗组503例和对照组527例.7项研究的合并分析结果显示,莫西沙星与肺结核SCR存在相关性(OR=1.37,95％ CI:1.04～1.81).结论莫西沙星提高了肺结核患者的SCR,可能是当前短疗程治疗药物敏感性肺结核的一种选择.
목적 계통평개항결핵약막서사성여폐결핵담전화솔(SCR)적상관성.방법 검색중국지망(CNKI)、유보중문과기기간전문수거고화만방수거고등중문수거고이급미국국립도서관(PubMed)、하란의학문적(EMBASE)화Cochrane도서관등영문수거고,운용Meta분석방법종합평개막서사성여폐결핵SCR적상관성.문헌자료사용RevMan4.2연건진행Meta분석.결과 공납입7편연구,포함치료조503례화대조조527례.7항연구적합병분석결과현시,막서사성여폐결핵SCR존재상관성(OR=1.37,95％ CI:1.04～1.81).결론 막서사성제고료폐결핵환자적SCR,가능시당전단료정치료약물민감성폐결핵적일충선택.
Objective To explore the relation of anti-tuberculosis drug moxifloxacin to the sputum conversion rate (SCR) in pulmonary tuberculosis patients.Methods The Chinese database including CNKI,CQVIP,and Wanfang database and the English database including Pubmed,EMBASE and Cochrane were all searched to retrieve literatures related to evaluation of moxifloxacin and SCR in pulmonary tuberculosis.The document data were meta-analyzed by RevMan4.2 software.Results Seven studies were ultimately included in this study.There were 503 cases in treatment group and 527 cases in control group.The odd ratio of moxifloxacin to SCR was 1.37 (95％CI:1.04-1.81).Conclusions The result indicates that treatment of moxifloxacin improve the SCR in pulmonary tuberculosis patients and is a choice of short-course therapy for drug-susceptible tuberculosis.