国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2014年
4期
258-260
,共3页
结核,肺%结核菌素试验%预防性服药
結覈,肺%結覈菌素試驗%預防性服藥
결핵,폐%결핵균소시험%예방성복약
Tuberculosis,pulmonary%PPD test%Preventive medication
目的 对学校涂阳肺结核疫情发生后密切接触者进行筛查,并观察预防性服药的效果.方法 选取2008-2012年嵊州市6起学校涂阳肺结核,疫情发生后密切接触者和一般接触者进行结核菌素试验(PPD试验),PPD强阳性胸片未见异常者建议给予抗结核预防性服药,并随访观察预防性服药的效果.结果 6起学校肺结核疫情共确诊肺结核34例,密切接触者710人,一般接触者190人.密切接触者中179名PPD筛查呈强阳性,其中86名开展预防性服药,随访1年无人发病;93名未服药的学生随访1年后,23人(24.73％)发病.预防性服药过程中,4人出现轻度的胃肠道反应,3人出现肝功能异常,停药好转后继续治疗,无严重不良反应发生.结论 通过PPD试验筛查,掌握密切接触者结核分枝杆菌感染状况,有针对性地进行预防性服药,能有效控制结核病扩散.
目的 對學校塗暘肺結覈疫情髮生後密切接觸者進行篩查,併觀察預防性服藥的效果.方法 選取2008-2012年嵊州市6起學校塗暘肺結覈,疫情髮生後密切接觸者和一般接觸者進行結覈菌素試驗(PPD試驗),PPD彊暘性胸片未見異常者建議給予抗結覈預防性服藥,併隨訪觀察預防性服藥的效果.結果 6起學校肺結覈疫情共確診肺結覈34例,密切接觸者710人,一般接觸者190人.密切接觸者中179名PPD篩查呈彊暘性,其中86名開展預防性服藥,隨訪1年無人髮病;93名未服藥的學生隨訪1年後,23人(24.73％)髮病.預防性服藥過程中,4人齣現輕度的胃腸道反應,3人齣現肝功能異常,停藥好轉後繼續治療,無嚴重不良反應髮生.結論 通過PPD試驗篩查,掌握密切接觸者結覈分枝桿菌感染狀況,有針對性地進行預防性服藥,能有效控製結覈病擴散.
목적 대학교도양폐결핵역정발생후밀절접촉자진행사사,병관찰예방성복약적효과.방법 선취2008-2012년승주시6기학교도양폐결핵,역정발생후밀절접촉자화일반접촉자진행결핵균소시험(PPD시험),PPD강양성흉편미견이상자건의급여항결핵예방성복약,병수방관찰예방성복약적효과.결과 6기학교폐결핵역정공학진폐결핵34례,밀절접촉자710인,일반접촉자190인.밀절접촉자중179명PPD사사정강양성,기중86명개전예방성복약,수방1년무인발병;93명미복약적학생수방1년후,23인(24.73％)발병.예방성복약과정중,4인출현경도적위장도반응,3인출현간공능이상,정약호전후계속치료,무엄중불량반응발생.결론 통과PPD시험사사,장악밀절접촉자결핵분지간균감염상황,유침대성지진행예방성복약,능유효공제결핵병확산.
Objective To screen the close contacts of smear-positive tuberculosis patients and investigate the effect of preventive medicine in closely contacted students in school.Methods Close contacts and general contacts in 6 schools with smear-positive pulmonary tuberculosis epidemic from 2008 to 2012 in Shengzhou city were tested by PPD.Students with strong PPD-positive but negative chest X-ray images were recommended to take anti-tuberculosis drugs,and the effect was evaluated.Results A total of 34 cases of pulmonary tuberculosis were diagnosed in the epidemic in 6 schools and 710 close contacts and 190 general contacts were identified.There were 179 strong PPD-positive students in 710 close contacts of tuberculosis patients.Among the strong PPD-positive students,86 took preventive medication and no patients were found one year later.Among 93 strong PPD-positive students who did not take preventive medicine,23 students (24.73％) developed tuberculosis one year later.Conclusions The status of tuberculosis infection in close contact population can be evaluated by PPD screening.PPD screening is useful to guide the preventive medication and thus effectively control the spread of tubuculosis.
