国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2013年
2期
97-100,111
,共5页
瘦素%调节性T细胞%能量代谢%Leptin-mTOR
瘦素%調節性T細胞%能量代謝%Leptin-mTOR
수소%조절성T세포%능량대사%Leptin-mTOR
Leptin%Regulatory T%Energy metabolism%Leptin-mTOR
瘦素是一类脂肪源性细胞因子,参与机体的自身免疫性疾病、炎症和免疫应答等的发生发展；调节性T细胞(Treg)是一类具有免疫抑制作用的T细胞亚群,参与调控上述病理进程.瘦素通过Leptin-mTOR通路对Treg的生成、增殖和功能发挥负向调节信号,因此,对此信号通路机制的深入研究可以为疾病的诊治提供新方法.
瘦素是一類脂肪源性細胞因子,參與機體的自身免疫性疾病、炎癥和免疫應答等的髮生髮展；調節性T細胞(Treg)是一類具有免疫抑製作用的T細胞亞群,參與調控上述病理進程.瘦素通過Leptin-mTOR通路對Treg的生成、增殖和功能髮揮負嚮調節信號,因此,對此信號通路機製的深入研究可以為疾病的診治提供新方法.
수소시일류지방원성세포인자,삼여궤체적자신면역성질병、염증화면역응답등적발생발전；조절성T세포(Treg)시일류구유면역억제작용적T세포아군,삼여조공상술병리진정.수소통과Leptin-mTOR통로대Treg적생성、증식화공능발휘부향조절신호,인차,대차신호통로궤제적심입연구가이위질병적진치제공신방법.
Leptin,a kind of adipose-derived cytokines,is involved in the genesis and development of autoimmune diseases,inflammation and immune responses; Regulatory T cells (Treg) with immunosuppressive effects,which are a small subset of T cells,are involved in the regulation of these pathological processes.Leptin plays a negative signaling regulatory effect on the generation,proliferation and function of Tregs via LeptinmTOR pathway.Therefore,the furhter study of the mechanism of Leptin-mTOR signaling pathway might provide new strategies for the diagnosis and treatment of diseases.
