CAJ | 학술논문

NOD1和NOD 2蛋白为胞浆内模式识别受体,其识别进入胞内的细菌胞壁及其降解产物,介导NF-κB和MAPKs信号途径,产生相关效应分子,介导了抗病原微生物免疫应答.近年来的最新研究发现,NOD1受体还通过ISGF3信号途径诱导产生1型干扰素,NOD2受体能识别ssRNA和病毒基因组ssRNA,通过MAVs信号途径激活IRF3,诱导产生1型干扰素,1型干扰素又可正向调控NOD1和NOD2功能性表达.NOD1和NOD2通过介导新的信号途径诱导产生大量的1型干扰素,并参与抗病毒固有免疫应答.因而,对NOD1和NOD2介导的抗病毒免疫应答新认识,将为防治病毒感染性疾病的研究提供新策略.
NOD1화NOD 2단백위포장내모식식별수체,기식별진입포내적세균포벽급기강해산물,개도NF-κB화MAPKs신호도경,산생상관효응분자,개도료항병원미생물면역응답.근년래적최신연구발현,NOD1수체환통과ISGF3신호도경유도산생1형간우소,NOD2수체능식별ssRNA화병독기인조ssRNA,통과MAVs신호도경격활IRF3,유도산생1형간우소,1형간우소우가정향조공NOD1화NOD2공능성표체.NOD1화NOD2통과개도신적신호도경유도산생대량적1형간우소,병삼여항병독고유면역응답.인이,대NOD1화NOD2개도적항병독면역응답신인식,장위방치병독감염성질병적연구제공신책략.
NOD1 and NOD2 are two intracellular pattern recognition receptors.They sense the major component of bacterial cell walls and their degradated products,then mediate NF-κB and MAPKs signaling pathways to produce the effector molecules involved in the antipathogenic immune response.Furthermore,it has been found in the recent years that NOD1 induces the production of type I interferon through ISGF3 signaling pathways and that NOD2 could recognise virus RNA and activate the MAVs-IRF3 signaling pathways to produce type I interferon.Type Ⅰ interferon could also positively regulate NOD1 and NOD2 functional expression.There-fore,NOD1 and NOD2 induce to large amounts of interferon to mediate innate immune antiviral responses by the aforementioned signaling pathways.Collectively,further understanding the antiviral immune responses mediated by NOD1 and NOD2 may provide new opportunities and strategies for the prevention and treatment of viral infections.