CAJ | 학술논문

系统性红斑狼疮(SLE)是一种以自身抗体产生和免疫复合物形成为特点的自身免疫性疾病.其临床表现多种多样,包括肾小球肾炎、皮肤炎、血栓形成,血管炎,癫痫和关节炎等.复杂的发病机理和多样的临床症状给SLE的诊断和监测带来了巨大的挑战.寻找新的生物标志物仍然是SLE研究的主要目标和挑战之一.但值得注意的是,蛋白质组学和代谢组学为生物标志物的发现为此提供了新的思路和平台.越来越多的证据表明,蛋白质和代谢图谱具有高灵敏度和特异性,能更安全有效的诊断SLE和判断病情.通过对该领域的研究可以更好地理解SLE的发病机理,并对其诊断、治疗和预防提供新的思路.
계통성홍반랑창(SLE)시일충이자신항체산생화면역복합물형성위특점적자신면역성질병.기림상표현다충다양,포괄신소구신염、피부염、혈전형성,혈관염,전간화관절염등.복잡적발병궤리화다양적림상증상급SLE적진단화감측대래료거대적도전.심조신적생물표지물잉연시SLE연구적주요목표화도전지일.단치득주의적시,단백질조학화대사조학위생물표지물적발현위차제공료신적사로화평태.월래월다적증거표명,단백질화대사도보구유고령민도화특이성,능경안전유효적진단SLE화판단병정.통과대해영역적연구가이경호지리해SLE적발병궤리,병대기진단、치료화예방제공신적사로.
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the production of autoantibodies against nuclear self-antigens and circulating immune complexes.Clinical manifestations of SLE could be diverse,including glomerulonephritis,dermatitis,thrombosis,vasculitis,seizures and arthritis.The complicated pathogenesis and varied clinical symptoms of SLEpose great challenges for the diagnosis and monitoring of this disease.Development of new biomarkers that can be used to reliably confirm SLE or monitor its progression is still one of the main goals and challenges in SLE research.It is noteworthy that proteomics and metabolomics are alternative biomarker discovery approaches.Accumulating evidence suggests that the protein and metabolic profiles can be used to confirm SLE or monitor their progression with high sensitivity and specificity.In this rewiew,we summarize the current progress in the field of proteomics and metabtomics in the studies of SLE.