国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2013年
6期
476-479
,共4页
乙型肝炎%FoxB1因子%HBV-DNA载量%谷丙转氨酶
乙型肝炎%FoxB1因子%HBV-DNA載量%穀丙轉氨酶
을형간염%FoxB1인자%HBV-DNA재량%곡병전안매
Hepatitis B%FoxB1 factor%HBV-DNA copies%Alanine transaminase
目的 研究FoxB1在乙型肝炎发生、发展中表达的临床意义.方法 ①收集临床确诊为乙型肝炎并排除甲、丙、丁、戊型肝炎病毒合并感染的乙肝住院病人血清278例,其中进展为肝硬化阶段者14例,肝癌阶段者12例,并随机抽取60名健康者血清,检测乙型肝炎病毒(HBV) DNA载量、FoxB1浓度和丙氨酸氨基转移酶活性;②分析乙型肝炎病人血清中FoxB1浓度与HBV-DNA载量谷丙转氨酶(ALT)活性的相关性,并依据乙型肝炎患者不同病情进展程度,分别比较肝癌组、肝硬化组、乙型肝炎组与健康组之间FoxBl因子浓度的差异.结果 ①278例肝炎病人血清中,HBV-DNA载量≥105拷贝/ml组FoxB1因子浓度为(12.5±6.9) pg/ml,HBV-DNA载量＜105拷贝/ml组为(12.7±9.3)pg/ml,健康人群组为(12.2 ±9.7)pg/ml,三组间FoxB1浓度无统计学意义(P＞0.05).②278例ALT异常组血清中FoxB1浓度为(17.4±20.5)pg/ml,健康对照组血清中FoxB1浓度为(12.2±9.7)pg/ml,ALT异常组FoxB1浓度略高于健康对照组(P＜0.05),血清FoxB1水平与ALT呈正相关(r=0.701).③乙型肝炎组FoxB1浓度为(12.6±8.7)pg/ml,肝硬化组为(60.1±38.1)pg/ml、肝癌组为(68.5±37.3) pg/ml,肝癌组、肝硬化组中FoxB1浓度显著高于乙型肝炎组(P＜0.05),而肝癌组与肝硬化组之间比较差异无统计学意义(P＞0.05).结论 FoxB1水平与肝细胞损伤ALT释放有关,可能参与肝癌病变,对乙型肝炎演化为肝硬化、肝癌有一定的预示作用,可作为病情进展的风险因子,并且可能成为治疗乙型肝炎病毒所致肝硬化、肝癌的新靶标.
目的 研究FoxB1在乙型肝炎髮生、髮展中錶達的臨床意義.方法 ①收集臨床確診為乙型肝炎併排除甲、丙、丁、戊型肝炎病毒閤併感染的乙肝住院病人血清278例,其中進展為肝硬化階段者14例,肝癌階段者12例,併隨機抽取60名健康者血清,檢測乙型肝炎病毒(HBV) DNA載量、FoxB1濃度和丙氨痠氨基轉移酶活性;②分析乙型肝炎病人血清中FoxB1濃度與HBV-DNA載量穀丙轉氨酶(ALT)活性的相關性,併依據乙型肝炎患者不同病情進展程度,分彆比較肝癌組、肝硬化組、乙型肝炎組與健康組之間FoxBl因子濃度的差異.結果 ①278例肝炎病人血清中,HBV-DNA載量≥105拷貝/ml組FoxB1因子濃度為(12.5±6.9) pg/ml,HBV-DNA載量＜105拷貝/ml組為(12.7±9.3)pg/ml,健康人群組為(12.2 ±9.7)pg/ml,三組間FoxB1濃度無統計學意義(P＞0.05).②278例ALT異常組血清中FoxB1濃度為(17.4±20.5)pg/ml,健康對照組血清中FoxB1濃度為(12.2±9.7)pg/ml,ALT異常組FoxB1濃度略高于健康對照組(P＜0.05),血清FoxB1水平與ALT呈正相關(r=0.701).③乙型肝炎組FoxB1濃度為(12.6±8.7)pg/ml,肝硬化組為(60.1±38.1)pg/ml、肝癌組為(68.5±37.3) pg/ml,肝癌組、肝硬化組中FoxB1濃度顯著高于乙型肝炎組(P＜0.05),而肝癌組與肝硬化組之間比較差異無統計學意義(P＞0.05).結論 FoxB1水平與肝細胞損傷ALT釋放有關,可能參與肝癌病變,對乙型肝炎縯化為肝硬化、肝癌有一定的預示作用,可作為病情進展的風險因子,併且可能成為治療乙型肝炎病毒所緻肝硬化、肝癌的新靶標.
목적 연구FoxB1재을형간염발생、발전중표체적림상의의.방법 ①수집림상학진위을형간염병배제갑、병、정、무형간염병독합병감염적을간주원병인혈청278례,기중진전위간경화계단자14례,간암계단자12례,병수궤추취60명건강자혈청,검측을형간염병독(HBV) DNA재량、FoxB1농도화병안산안기전이매활성;②분석을형간염병인혈청중FoxB1농도여HBV-DNA재량곡병전안매(ALT)활성적상관성,병의거을형간염환자불동병정진전정도,분별비교간암조、간경화조、을형간염조여건강조지간FoxBl인자농도적차이.결과 ①278례간염병인혈청중,HBV-DNA재량≥105고패/ml조FoxB1인자농도위(12.5±6.9) pg/ml,HBV-DNA재량＜105고패/ml조위(12.7±9.3)pg/ml,건강인군조위(12.2 ±9.7)pg/ml,삼조간FoxB1농도무통계학의의(P＞0.05).②278례ALT이상조혈청중FoxB1농도위(17.4±20.5)pg/ml,건강대조조혈청중FoxB1농도위(12.2±9.7)pg/ml,ALT이상조FoxB1농도략고우건강대조조(P＜0.05),혈청FoxB1수평여ALT정정상관(r=0.701).③을형간염조FoxB1농도위(12.6±8.7)pg/ml,간경화조위(60.1±38.1)pg/ml、간암조위(68.5±37.3) pg/ml,간암조、간경화조중FoxB1농도현저고우을형간염조(P＜0.05),이간암조여간경화조지간비교차이무통계학의의(P＞0.05).결론 FoxB1수평여간세포손상ALT석방유관,가능삼여간암병변,대을형간염연화위간경화、간암유일정적예시작용,가작위병정진전적풍험인자,병차가능성위치료을형간염병독소치간경화、간암적신파표.
Objective To investigate the clinical significance of FoxB1 in the hepatitis B' s occurrence and development.Method ①Except infected with hepatitis A,C,D or E virus,Sera of 278 hepatitis B patients were collected,in which 14 were cirrus patients and 12 were hepatocellular carcinoma (HCC) patients.60 sera of healthy were also collected.Concentration of FoxB1 factor was detected in these sera.And other relevant clinical information,alanine transaminase (ALT) activity data and hepatitis B virus (HBV) DNA copies were collected.②The correlation was analyzed among the concentration of FoxB1 factors、HBV-DNA and ALT activity.Furthermore,the differences was analyzed on concentration of FoxB1 factors in the groups of liver cancer,liver cirrhosis,Hepatitis B and the healthy.Results ①In 278 cases of hepatitis B patients,FoxB1 of ≥105 copies/ml group was(12.5 ± 6.9) pg/ml,and ＜ 105 group was(12.7 ± 9.3) pg/ml,and healthy control was (12.2 ±9.7)pg/ml.There is no significant FoxB1 factors differenceamong the three groups of "≥105copies/ml group"," ＜ 105 copies/ml group "and" the healthy group" (P ＜ 0.05).②FoxB1 concentration was (17.4 ± 20.5) pg/ml in 278 cases of sera with high ALT activity,healthy control was(12.2 ± 9.7) pg/ml.FoxB1 was higher in the high ALT group than in the healthy (P ＜0.05).There was positively correlation between concentration of FoxB1 factors and ALT activity (r =0.701).③FoxB1 concentrations of the hepatitis B patients was(12.6 ± 8.7) pg/ml,cirrhosis group was (60.1 ± 38.1) pg/ml,and liver cancer group was (68.5 ±37.3)pg/ml.FoxB1 concentration was higher in cirrhosis and liver cancer groups than in hepatitis B group and healthy people (P ＜ 0.05) ; There was no significant difference between in hepatocellular carcinoma group and cirrhosis group (P ＞ 0.05).Conclusion FoxB1 is associated with hepatocyte damage and may involve in hepatocellular carcinogenesis.It may be foretell of liver cirrhosis and HCC occurrence as a risk factor for hepatitis B progression.In the future,FoxBl may serve as a novel target for liver cirrhosis and HCC preventing and therapy.
