CAJ | 학술논문

目的评价舌下含服粉尘螨滴剂治疗过敏性鼻炎的临床疗效,为临床预防诊治提供依据.方法采用治疗前后对照,比较98例尘螨过敏性鼻炎患者在接受两年舌下含服粉尘螨滴剂治疗前、后的体征及症状评分,评估舌下含服粉尘螨滴剂治疗的疗效,统计不良反应发生率并对患者进行指导.结果治疗两年后,患者症状评分及体征评分较治疗前均明显减少,儿童组症状总分由治疗前10.27±1.87降至4.34±1.57;成人组症状总分由治疗前11.26±1.54降至5.81±1.52,差异有统计学意义(P＜0.05).儿童组体征得分由治疗前2.78±0.68降至1.54±0.57;成人组体征得分由治疗前2.86±0.59降至1.82±0.41,差异有统计学意义(P＜0.05).儿童组治疗有效率为94.74％,成人组治疗有效率为88.33％,总有效率为91.54％.5例患者(5.10％)出现局部不良反应,3例(3.06％)出现全身轻微不良反应,未出现全身严重不良反应.结论舌下含服粉尘螨滴剂治疗过敏性鼻炎是一种安全有效的方法,疗效确切、患者痛苦小、不良反应发生率低,值得临床大范围推广和使用.
목적 평개설하함복분진만적제치료과민성비염적림상료효,위림상예방진치제공의거.방법 채용치료전후대조,비교98례진만과민성비염환자재접수량년설하함복분진만적제치료전、후적체정급증상평분,평고설하함복분진만적제치료적료효,통계불량반응발생솔병대환자진행지도.결과 치료량년후,환자증상평분급체정평분교치료전균명현감소,인동조증상총분유치료전10.27±1.87강지4.34±1.57;성인조증상총분유치료전11.26±1.54강지5.81±1.52,차이유통계학의의(P＜0.05).인동조체정득분유치료전2.78±0.68강지1.54±0.57;성인조체정득분유치료전2.86±0.59강지1.82±0.41,차이유통계학의의(P＜0.05).인동조치료유효솔위94.74％,성인조치료유효솔위88.33％,총유효솔위91.54％.5례환자(5.10％)출현국부불량반응,3례(3.06％)출현전신경미불량반응,미출현전신엄중불량반응.결론 설하함복분진만적제치료과민성비염시일충안전유효적방법,료효학절、환자통고소、불량반응발생솔저,치득림상대범위추엄화사용.
Objective To evaluate the clinical efficacy of dermatophagoides farinae drops through sublingual clothing in treatment of allergic rhinitis,thus to provide scientific evidence for the clinical prevention and treatment of the disease.Methods To compare the symptom's difference pre and after treatment in 98 patients with allergic rhinitis in 2 years through sublingual clothing and the treating signs' assessment,to assess the efficiency of dermatophagoides farinae drops through sublingual clothing and record the statistical incidence of adverse reaction.Results After 2 years' treatment,patients' score of symptom and objective sign were all significantly decreased than pre-treatment(P ＜ 0.05).the score of symptom in children group was decreased from 10.27 ± 1.87 to 4.34 ± 1.57 after treatment and the score in adult group was decreased from 11.26 ± 1.54 to 5.81 ± 1.52,the statistic difference were significant(P ＜ 0.05).the score of objective sign in children group was decreased from 2.78 ± 0.68 to 1.54 ± 0.57 after treatment and the score in adult group was decreased from 2.86 ±0,59 to 1.82 ±0.41,the statistic difference were sign ificant(P ＜0.05).The effective rate in children was 94.74％,the Adult effective rate was 88.33％,and the total effective rate was 91.54％.Local adverse reactions occurred in five cases (5.10％),slight adverse reactions in three cases (3.06％),and there were no serious adverse reactions.Conclusion Dermatophagoides farinae drops through sublingnal clothing are a highly effective and safe for the treatment of allergic rhinitis,and it is worth to applying to wide clinical application for its proved curative effect,little distress and lower adverse effect.