CAJ | 학술논문

目的探讨肾活检组织内乙肝病毒标志物在乙肝病毒相关性肾炎(HBV-GN)中的表达意义及HBV-GN的临床病理特点.方法应用免疫荧光法和免疫组化SP法,分别在石腊切片和冰冻切片中检测肾活检组织内HBV标志物.结果 2001年1月至2012年10月肾活检确诊为HBV-GN的144例患者,经免疫组织化学检测,证实HBV标志物阳性率在病例中以膜性肾病最高(117例,占81.2％),膜增殖性肾小球肾炎次之(21例,占4.5％),阳性物质沉积于毛细血管袢或系膜区.结论鉴于我国是HBV的高感染地区,在肾活检组织中常规检测HBV标志物,对HBV-GN的早期诊断具有重要意义.
목적 탐토신활검조직내을간병독표지물재을간병독상관성신염(HBV-GN)중적표체의의급HBV-GN적림상병리특점.방법 응용면역형광법화면역조화SP법,분별재석석절편화빙동절편중검측신활검조직내HBV표지물.결과 2001년1월지2012년10월신활검학진위HBV-GN적144례환자,경면역조직화학검측,증실HBV표지물양성솔재병례중이막성신병최고(117례,점81.2％),막증식성신소구신염차지(21례,점4.5％),양성물질침적우모세혈관번혹계막구.결론 감우아국시HBV적고감염지구,재신활검조직중상규검측HBV표지물,대HBV-GN적조기진단구유중요의의.
Objective To explore the significance of the presence of HBV markers in renal tissues from patients with hepatitis B virus-associated glomerulonephritis(HBV-GN) and the clinicopathologic features of HBV-GN.Methods The 144 cases with HBV-GN confirmed by renal biopsy from January 2001 to October 2012 were collected.The kidney biopsy were studied by immunofluorescence and immunohistochemical SP method for HBV markers in paraffin and frozen sections.Results Immunohistochemistry showed positive HBV markers in 117 membranous nephropathy cases (81.2％) and 21 membranoproliferative glomerulonephritis cases(4.5％).HBV markers were located in capillary and mesanginm.Conclusion Due to the high incidence of HBV in China,routine detection of HBV markers in kidney biopsy is of great significance for early diagnosis of HBV-GN.