CAJ | 학술논문

背景阿片类药物引起的痛觉过敏(opioid-induced hyperalgesia,OIH)日益引起关注,其机制有待深入研究.目的论述脊髓水平OIH的机制,以供临床研究防治此类痛觉过敏参考.内容就脊髓水平受体通路、信号转导路径及神经肽等方面,论述OIH的机制.趋向脊髓水平多种途径参与OIH,值得进一步研究.
배경 아편류약물인기적통각과민(opioid-induced hyperalgesia,OIH)일익인기관주,기궤제유대심입연구.목적 논술척수수평OIH적궤제,이공림상연구방치차류통각과민삼고.내용 취척수수평수체통로、신호전도로경급신경태등방면,논술OIH적궤제.추향 척수수평다충도경삼여OIH,치득진일보연구.
Background Opioid-induced hyperalgesia has received increasing attention,and the mechanisms need further investigation.Objective To expound some possible mechanisms of opioid-induced hyperalgesia in the spinal cord level,which may offer some methods for prevention of the hyperalgesia in clinic.Content This review provides some information about opioidinduced hyperalgesia in the spinal cord level,such as the receptors pathway,signal transduction pathway,neuropeptide and so on.Trend The detailed mechanism of opioid-induced hyperalgesia in the spinal cord level needs further study.