国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2013年
1期
62-65
,共4页
非甾体抗炎药物%结直肠/吻合口%吻合口漏%愈合
非甾體抗炎藥物%結直腸/吻閤口%吻閤口漏%愈閤
비치체항염약물%결직장/문합구%문합구루%유합
Non-steroidal anti-inflammatory drugs%Colorectal anastomosis%Anastomosis leakage%Heal
背景 非甾体抗炎药物(non-steroidal anti-inflammatory drugs,NSAIDs)是一类具有抗炎、镇痛和解热等作用的药物,其主要通过抑制环氧化物酶阻断花生四烯酸合成前列腺素而发挥解热、镇痛、抗炎作用.近年来,NSAIDs与麻醉药品并用于围手术期镇痛取得了良好的临床效果,尤其被广泛应用于手术后镇痛. 目的 吻合口漏是结直肠外科最严重的并发症之一,NSAIDs是否影响结直肠吻合口的愈合、增加吻合口漏的发生率文献报道不一. 内容 总结近年来关于NSAIDs对人体及实验动物结直肠吻合口愈合影响的代表性文献. 趋向 为手术后合理、安全使用NSAIDs提供参考,并总结NSAIDs对结直肠吻合口愈合影响的可能的机制.
揹景 非甾體抗炎藥物(non-steroidal anti-inflammatory drugs,NSAIDs)是一類具有抗炎、鎮痛和解熱等作用的藥物,其主要通過抑製環氧化物酶阻斷花生四烯痠閤成前列腺素而髮揮解熱、鎮痛、抗炎作用.近年來,NSAIDs與痳醉藥品併用于圍手術期鎮痛取得瞭良好的臨床效果,尤其被廣汎應用于手術後鎮痛. 目的 吻閤口漏是結直腸外科最嚴重的併髮癥之一,NSAIDs是否影響結直腸吻閤口的愈閤、增加吻閤口漏的髮生率文獻報道不一. 內容 總結近年來關于NSAIDs對人體及實驗動物結直腸吻閤口愈閤影響的代錶性文獻. 趨嚮 為手術後閤理、安全使用NSAIDs提供參攷,併總結NSAIDs對結直腸吻閤口愈閤影響的可能的機製.
배경 비치체항염약물(non-steroidal anti-inflammatory drugs,NSAIDs)시일류구유항염、진통화해열등작용적약물,기주요통과억제배양화물매조단화생사희산합성전렬선소이발휘해열、진통、항염작용.근년래,NSAIDs여마취약품병용우위수술기진통취득료량호적림상효과,우기피엄범응용우수술후진통. 목적 문합구루시결직장외과최엄중적병발증지일,NSAIDs시부영향결직장문합구적유합、증가문합구루적발생솔문헌보도불일. 내용 총결근년래관우NSAIDs대인체급실험동물결직장문합구유합영향적대표성문헌. 추향 위수술후합리、안전사용NSAIDs제공삼고,병총결NSAIDs대결직장문합구유합영향적가능적궤제.
Background Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of drugs with effects of antiinflammatory,analgesic and antipyretic.It is main by the way of blocking arachidonic acid synthesis of prostaglandins by inhibiting epoxide hydrolase to achieve the effects of antipyretic,analgesic and anti-inflammatory.In recent years,use of NSAIDS with narcotic drugs for perioperative analgesia achieved good clinical result,it particularly widely used in post-operative analgesia.Objective Anastomotic leakage is one of the most serious complications in colorectal surgery.The reports about whether NSAIDs affect colorectal anastomotic healing and increase the incidence of anastomotic leak are different.Content This review summarizes representative literature NSAIDs colorectal anastomotic healing in humans and experimental animals in recent years.Trend This review provides a reference for the safe use of NSAIDs and summarizs the impact of NSAIDs on colorectal anastomotic healing mechanism.
