国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2013年
1期
66-69
,共4页
组蛋白脱乙酰化酶抑制剂%失血性休克%感染性休克
組蛋白脫乙酰化酶抑製劑%失血性休剋%感染性休剋
조단백탈을선화매억제제%실혈성휴극%감염성휴극
Histone deacetylase inhibitors%Hemorrhagic shock%Septic shock
背景 休克早期的药物救治,一直普遍受到关注,近来组蛋白脱乙酰化酶抑制剂(histone deacetylase inhibitors,HDACI)因其突出的抗休克作用成为国际研究热点. 目的 回顾目前HDACI的临床应用方向和分类,讨论其作为抗失血性休克和感染性休克药物的突出优势以及作用机制. 内容 HDACI可通过抗细胞凋亡等多种途径,提高细胞对休克所致缺血/缺氧环境的耐受能力,改善失血性休克和感染性休克动物模型的预后. 趋向 HDACI已成为抗失血性休克和感染性休克研究的新方向,是提高休克早期生存率的新策略,也为休克的治疗提供了药物配合液体复苏的新途径.
揹景 休剋早期的藥物救治,一直普遍受到關註,近來組蛋白脫乙酰化酶抑製劑(histone deacetylase inhibitors,HDACI)因其突齣的抗休剋作用成為國際研究熱點. 目的 迴顧目前HDACI的臨床應用方嚮和分類,討論其作為抗失血性休剋和感染性休剋藥物的突齣優勢以及作用機製. 內容 HDACI可通過抗細胞凋亡等多種途徑,提高細胞對休剋所緻缺血/缺氧環境的耐受能力,改善失血性休剋和感染性休剋動物模型的預後. 趨嚮 HDACI已成為抗失血性休剋和感染性休剋研究的新方嚮,是提高休剋早期生存率的新策略,也為休剋的治療提供瞭藥物配閤液體複囌的新途徑.
배경 휴극조기적약물구치,일직보편수도관주,근래조단백탈을선화매억제제(histone deacetylase inhibitors,HDACI)인기돌출적항휴극작용성위국제연구열점. 목적 회고목전HDACI적림상응용방향화분류,토론기작위항실혈성휴극화감염성휴극약물적돌출우세이급작용궤제. 내용 HDACI가통과항세포조망등다충도경,제고세포대휴극소치결혈/결양배경적내수능력,개선실혈성휴극화감염성휴극동물모형적예후. 추향 HDACI이성위항실혈성휴극화감염성휴극연구적신방향,시제고휴극조기생존솔적신책략,야위휴극적치료제공료약물배합액체복소적신도경.
Baekgroud Histone deacetylase inhibitors(HDACI) received attention because of its outstanding protection role in the early pharmacological resuscitation of shock.Objective To review the clinical application and classification of HDACI,and discuss its advantages and mechanisms as a drug for hemorrhagic shock and septic shock.Content HDACI is promising to early survival of shock through its anti-apoptosis effect and many other mechanisms,offers considerable protection in the hemorrhagic shock and septic shock model.Trend HDACI is a new strategy for approving early survival,at the same time provide (provides) potential new clinical applications of shock in the future.
