CAJ | 학술논문

背景肿瘤坏死因子相关凋亡诱导配体(tumor necrosis factor related apoptosis induced ligand,TRAIL)是肿瘤坏死因子超家族成员之一,其与受体DR4/DR5结合可以诱导肿瘤细胞的凋亡,而备受关注. 目的总结TRAIL通路在脓毒症中的可能机制,探讨其在脓毒症疾病过程中的调控作用. 内容脓毒症动物模型的研究发现,TRAIL可以加快活化的中性粒细胞发生凋亡并参与脓毒症免疫耐受的形成. 趋势 TRAIL受体在肿瘤、自身免疫性疾病、感染、心血管疾病、器官移植等领域的研究越来越多,作用机制也在不断地阐明.TRAIL及其受体在脓毒症疾病过程中发挥重要调节作用.
배경 종류배사인자상관조망유도배체(tumor necrosis factor related apoptosis induced ligand,TRAIL)시종류배사인자초가족성원지일,기여수체DR4/DR5결합가이유도종류세포적조망,이비수관주. 목적 총결TRAIL통로재농독증중적가능궤제,탐토기재농독증질병과정중적조공작용. 내용 농독증동물모형적연구발현,TRAIL가이가쾌활화적중성립세포발생조망병삼여농독증면역내수적형성. 추세 TRAIL수체재종류、자신면역성질병、감염、심혈관질병、기관이식등영역적연구월래월다,작용궤제야재불단지천명.TRAIL급기수체재농독증질병과정중발휘중요조절작용.
Background Tumor necrosis factor related apoptosis induced ligand (TRAIL) is a new proapoptotic member of tumor necrosis factor superfamily which has been implicated in the regulation of apoptosis of tumor cell when bind to its receptor DR4/DRS.Objective To summarize the potential mechanism of TRAIL in the pathophysiology of sepsis.Content Based on researches using sepsis models,we concluded that TRAIL accelerates the apoptosis of activated neutrophil and this molecule was involved in the immunosupression.Trend Studies on TRAIL involved a variety of disciplines such as tumor therapy,autoimmune disease,cardiovascular disease,transplant,infections,trauma and so on.TRAIL played an important role in the regulation of immune response of septic host.