CAJ | 학술논문

背景作为远隔缺血处理(remote ischemic conditioning,RIPC)心肌保护最重要的效应因子,内源性介质已引起越来越多研究者的关注.目的综述RIPC心肌保护作用介质的相关研究.内容动物实验研究证实RIPC后收集动物的血液或冠脉流出液亦可对其他动物的心肌缺血/再灌注损伤(ischemia/reperfusion injury,I/RI)发挥明显的保护作用,但其机制尚未完全阐明.通过归纳目前的动物研究,作者从内源性保护介质的提出、成份鉴定及特性、细胞内信号机制进行系统描述.同时,概括来自人类的一些相关证据.趋势需要进一步研究来明确内源性介质的主要效应成份,为心肌保护药物开发提供新的思路.
배경 작위원격결혈처리(remote ischemic conditioning,RIPC)심기보호최중요적효응인자,내원성개질이인기월래월다연구자적관주.목적 종술RIPC심기보호작용개질적상관연구.내용 동물실험연구증실RIPC후수집동물적혈액혹관맥류출액역가대기타동물적심기결혈/재관주손상(ischemia/reperfusion injury,I/RI)발휘명현적보호작용,단기궤제상미완전천명.통과귀납목전적동물연구,작자종내원성보호개질적제출、성빈감정급특성、세포내신호궤제진행계통묘술.동시,개괄래자인류적일사상관증거.추세 수요진일보연구래명학내원성개질적주요효응성빈,위심기보호약물개발제공신적사로.
Background Endogenous mediators of remote ischemic conditioning (RIPC) have been drawn researchers' attention as the most important contributors.Objective This paper reviews the relative researches of endogenous mediators involved in the RIPC.Content Various animal studies have proved that the RIPC induced whole blood or coronary effluent from one organ can confer protective potential during ischemic/reperfusion injury (I/RI) in another heart.However,the exact mechanism remans unknown.The researchers have summerized the animal studies regarding the introduction,identification,characteristics and intracellular signal mechanisms of endogenous mediators.Meanwhile,some related evidences in human have also been listed.Trend The further studies are needed to ascertain the exact effective fraction of endogenous mediators in order to offer new idea for cardioprotective drug development.