CAJ | 학술논문

背景急性肾功能损伤(acute kidney injury,AKI)是心脏手术后严重并发症之一,国外报道发生率高于30％,严重影响患者术后恢复和生存率.阿司匹林是心血管疾病患者常用的治疗和预防药物. 目的综述近期围术期阿司匹林对心脏手术肾保护作用的临床研究结果并简要分析其可能机制. 内容多项回顾性临床调查和随机对照研究发现围术期使用阿司匹林可以减少心脏手术后AKI的发生,减少术后肾透析需要,降低死亡率并且明显改善患者的术后恢复. 趋势阿司匹林对心脏手术患者肾保护作用的机制尚需深入研究,维持肾脏血流灌注和减少炎性反应可能是主要原因.
배경 급성신공능손상(acute kidney injury,AKI)시심장수술후엄중병발증지일,국외보도발생솔고우30％,엄중영향환자술후회복화생존솔.아사필림시심혈관질병환자상용적치료화예방약물. 목적 종술근기위술기아사필림대심장수술신보호작용적림상연구결과병간요분석기가능궤제. 내용 다항회고성림상조사화수궤대조연구발현위술기사용아사필림가이감소심장수술후AKI적발생,감소술후신투석수요,강저사망솔병차명현개선환자적술후회복. 추세 아사필림대심장수술환자신보호작용적궤제상수심입연구,유지신장혈류관주화감소염성반응가능시주요원인.
Background Acute kidney injury (AKI) was one of the serious complication after cardiac surgery with reported incidence of more than 30％,which resulted in increased mortality.Aspirin was regularly used for therapy and prophylaxis in patients with cardiovascular diseases.Objective This review aims to present a general report of recent studies about the benefits of aspirin on renal function after cardiac surgery and analyse its possible mechanisms.Content Recent retrospective clinical investigations and randomised controlled trails indicated that aspirin significantly decreased the incidence of AKI (acute renal injury/dysfunction),in-hospital mortality,accepted dialysis and improved outcomes after cardiac surgery.Trend The protective mechanisms for renal after cardiac surgery by preoperative administration of aspirin still need further investigation.The main mechanisms may be relate to maintain renal blood perfusion and reduce inflammatory reaction.