CAJ | 학술논문

背景过度灌注综合征(hyperperfusion syndrome,CHS)是颈动脉血管重建术后少见而又严重的并发症,若未及时发现将会导致术后患者颅内出血甚至死亡. 目的对这一并发症的全面认识将有助于临床医生及时发现患者病情并尽早干预从而减少其发病率和死亡率. 内容从病理生理机制、临床表现、危险因素、诊断、评估过度灌注方法及治疗等方面对这一术后并发症进行综述. 趋向目前对这一并发症的机制还不明确,也缺乏贴合临床的动物模型,在今后的研究中希望可以建立相关的动物模型从而对其发病机制进行深入研究,为临床防治CHS提供新的治疗依据.
배경 과도관주종합정(hyperperfusion syndrome,CHS)시경동맥혈관중건술후소견이우엄중적병발증,약미급시발현장회도치술후환자로내출혈심지사망. 목적 대저일병발증적전면인식장유조우림상의생급시발현환자병정병진조간예종이감소기발병솔화사망솔. 내용 종병리생리궤제、림상표현、위험인소、진단、평고과도관주방법급치료등방면대저일술후병발증진행종술. 추향 목전대저일병발증적궤제환불명학,야결핍첩합림상적동물모형,재금후적연구중희망가이건립상관적동물모형종이대기발병궤제진행심입연구,위림상방치CHS제공신적치료의거.
Background Cerebral hyperperfusion syndrome(CHS) is a rare,serious complication after carotid revascularization,which could lead to severe intracerebral hemorrhage and death if it is not timely discovered.Objective To summarize this syndrome for dealing with this complication and reducing the morbidity and mortality caused by CHS.Content This review includes pathophysiology,clinical manifestation,risk factors,diagnostic modalities,and disease management of complication after carotid revascularization.Trend It is difficult to clarify the mechanism of CHS because there is no suitable animal model of CHS at present.Therefore,more researches should be focused on establishing the animal models in order to clarify its mechanisms in future.The results obtained will not only enrich our understanding of CHS,but also provide therapeutic foundation for hyperperfusion and related diseases.