CAJ | 학술논문

背景活性氧在缺血/再灌注损伤(ischemia/reperfusion,Ⅰ/RI)中发挥重要作用.越来越多的研究表明氢气(hydrogen,H2)通过选择性清除活性氧簇(reactive oxygen species,ROS)保护各种细胞、组织、器官免受氧化损伤. 目的分析总结氢对Ⅰ/R损伤的治疗作用及其可能机制,为更好地认识H2并将其应用于临床奠定基础. 内容 H2对Ⅰ/RI的作用机制并不明确,就H2对各器官Ⅰ/RI的治疗及可能机制进行阐述,并对H2作为一种治疗性气体在医学方面的应用前景做出展望.趋向 H2治疗Ⅰ/RI具有广阔的临床应用前景,但为了识别H2作用的确切机制及验证H2在临床上的治疗潜力还有很多工作要做.
배경 활성양재결혈/재관주손상(ischemia/reperfusion,Ⅰ/RI)중발휘중요작용.월래월다적연구표명경기(hydrogen,H2)통과선택성청제활성양족(reactive oxygen species,ROS)보호각충세포、조직、기관면수양화손상. 목적 분석총결경대Ⅰ/R손상적치료작용급기가능궤제,위경호지인식H2병장기응용우림상전정기출. 내용 H2대Ⅰ/RI적작용궤제병불명학,취H2대각기관Ⅰ/RI적치료급가능궤제진행천술,병대H2작위일충치료성기체재의학방면적응용전경주출전망.추향 H2치료Ⅰ/RI구유엄활적림상응용전경,단위료식별H2작용적학절궤제급험증H2재림상상적치료잠력환유흔다공작요주.
Background Reactive oxygen species (ROS) play an important role in ischemia/reperfusion injury (Ⅰ/RI).Accumulating evidence suggests that hydrogen can protect various cells,tissues and organs from oxidative injury by selectively scavenging ROS.Objective To analyse and review the effect and potential mechanisms of hydrogen in treatment of Ⅰ/RI,and to get more knowledge about hydrogen to make better clinical applications of hydrogen.Content The mechanisms of hydrogen in treating Ⅰ/R injury were not clear.This paper describes effect and potential mechanisms of hydrogen in treatment of Ⅰ/RI and makes prospect for research into hydrogen as a therapeutic gas in clinical applications.Trend Hydrogen in treating Ⅰ/RI has a wide prospect of clinical applications.However,more work is needed to find out the precise mechanisms underlying the actions of hydrogen and to validate its therapeutic potential in the clinical settings.