CAJ | 학술논문

背景神经突触具有高度可塑性,突触的形成和重塑是神经元活动依赖性的,是学习记忆、认知功能的基础.越来越多的证据表明阿尔茨海默病(alzheimer's disease,AD)早期出现的轻度认知功能下降与突触功能障碍相关. 目的对突触功能障碍在AD发病机制中的作用作一系统阐述. 内容近年来研究发现,AD患者脑内发生着明显的突触丢失的神经组织学改变,并多发生在认知缺失开始的早期;同时发现,突触的丢失程度与痴呆的严重程度密切相关,成为与认知缺失相关的一个重要的病理学特征. 趋势对突触功能障碍机制的深入研究可能为AD的早期干预和治疗开拓新的思路与方向.
배경 신경돌촉구유고도가소성,돌촉적형성화중소시신경원활동의뢰성적,시학습기억、인지공능적기출.월래월다적증거표명아이자해묵병(alzheimer's disease,AD)조기출현적경도인지공능하강여돌촉공능장애상관. 목적 대돌촉공능장애재AD발병궤제중적작용작일계통천술. 내용 근년래연구발현,AD환자뇌내발생착명현적돌촉주실적신경조직학개변,병다발생재인지결실개시적조기;동시발현,돌촉적주실정도여치태적엄중정도밀절상관,성위여인지결실상관적일개중요적병이학특정. 추세 대돌촉공능장애궤제적심입연구가능위AD적조기간예화치료개탁신적사로여방향.
Background Synapses are highly motile and can undergo remodeling even in the adult nervous system.Synapse remodeling and the formation of new synapses are activity-dependent processes that provide a basis for memory formation.There is growing evidence that mild cognitive impairment in early alzheimer's disease (AD) may be due to synaptic dysfunction.Objective To review the roles of synaptic dysfunction in AD.Content Recent work suggests that loss of synapses is an evident histoneurological change in the early stages of cognitive deficiency in AD.The extent of synaptic loss has been found to be an excellent correlate of the degree of dementia,so it has been shown to be the best pathologic correlate to cognitive decline.Trend Further research on this area may provide useful insights and directions into the early intervention and treatment of AD.