国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2014年
2期
162-164,177
,共4页
再灌注损伤%肾功能不全%呼吸窘迫综合征
再灌註損傷%腎功能不全%呼吸窘迫綜閤徵
재관주손상%신공능불전%호흡군박종합정
Reperfusion injury%Renal insufficiency%Respiratory distress syndrome
背景 肾脏缺血/再灌注(ischemia/reperfusion,I/R)不仅可导致肾损伤,还可引起肾外远隔脏器的损伤,甚至多器官功能障碍综合征(muhiple organ dysfunction syndrome,MODS),肺由于血管网庞大等原因,更容易受其影响而发生损伤.目的 综述肾脏I/R致肺损伤的可能机制及肺保护措施的研究现状.内容 主要总结肾脏I/R致肺损伤的细胞结构基础、发生机制及最新的肺保护措施.趋向 研究I/R致肺损伤的病理生理过程并探索有效的肺保护方法对降低此类患者死亡率及改善预后有重要意义.
揹景 腎髒缺血/再灌註(ischemia/reperfusion,I/R)不僅可導緻腎損傷,還可引起腎外遠隔髒器的損傷,甚至多器官功能障礙綜閤徵(muhiple organ dysfunction syndrome,MODS),肺由于血管網龐大等原因,更容易受其影響而髮生損傷.目的 綜述腎髒I/R緻肺損傷的可能機製及肺保護措施的研究現狀.內容 主要總結腎髒I/R緻肺損傷的細胞結構基礎、髮生機製及最新的肺保護措施.趨嚮 研究I/R緻肺損傷的病理生理過程併探索有效的肺保護方法對降低此類患者死亡率及改善預後有重要意義.
배경 신장결혈/재관주(ischemia/reperfusion,I/R)불부가도치신손상,환가인기신외원격장기적손상,심지다기관공능장애종합정(muhiple organ dysfunction syndrome,MODS),폐유우혈관망방대등원인,경용역수기영향이발생손상.목적 종술신장I/R치폐손상적가능궤제급폐보호조시적연구현상.내용 주요총결신장I/R치폐손상적세포결구기출、발생궤제급최신적폐보호조시.추향 연구I/R치폐손상적병리생리과정병탐색유효적폐보호방법대강저차류환자사망솔급개선예후유중요의의.
Background Renal ischemia/reperfusion (I/R) injury leads to renal and extrarenal organs injury,and even multiple organ dysfunction syndrome (MODS).The lung,as an organ with large microcapillary network,is highly susceptible to injury caused by renal I/R.Objective To review and summarize the mechanism of lung injury induced by renal I/R and the research development of pulmonary protection.Content This article reviews the cellular basic construction and the mechanism of lung injury induced by renal I/R injury,and the latest methods of pulmonary protection.Trend It is necessary to exploring the pathophysiological process and protective methods of lung injury by renal I/R to reduce the mortality.
