国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2014年
2期
173-177
,共5页
布比卡因脂质体%镇痛%药动学%药效学%安全性
佈比卡因脂質體%鎮痛%藥動學%藥效學%安全性
포비잡인지질체%진통%약동학%약효학%안전성
Liposomal bupivacaine%Analgesia%Pharmacokinetics%Pharmacodynamics%Safety efficacy
背景 布比卡因脂质体是一种新型的酰胺类局部麻醉药,是采用脂质体技术制备而成的缓释布比卡因.研究表明,布比卡因脂质体的局部镇痛作用时间可长达72 h.目的 拟对有关布比卡因脂质体的相关研究予以综述,重点介绍其在术后镇痛方面的相关研究进展.内容 从布比卡因脂质体的特性、药动学、药效学及安全性4个方面综述布比卡因脂质体在术后镇痛中的应用.趋向 布比卡因脂质体作为超长镇痛局麻药,在术后镇痛中将具有广泛的应用价值.
揹景 佈比卡因脂質體是一種新型的酰胺類跼部痳醉藥,是採用脂質體技術製備而成的緩釋佈比卡因.研究錶明,佈比卡因脂質體的跼部鎮痛作用時間可長達72 h.目的 擬對有關佈比卡因脂質體的相關研究予以綜述,重點介紹其在術後鎮痛方麵的相關研究進展.內容 從佈比卡因脂質體的特性、藥動學、藥效學及安全性4箇方麵綜述佈比卡因脂質體在術後鎮痛中的應用.趨嚮 佈比卡因脂質體作為超長鎮痛跼痳藥,在術後鎮痛中將具有廣汎的應用價值.
배경 포비잡인지질체시일충신형적선알류국부마취약,시채용지질체기술제비이성적완석포비잡인.연구표명,포비잡인지질체적국부진통작용시간가장체72 h.목적 의대유관포비잡인지질체적상관연구여이종술,중점개소기재술후진통방면적상관연구진전.내용 종포비잡인지질체적특성、약동학、약효학급안전성4개방면종술포비잡인지질체재술후진통중적응용.추향 포비잡인지질체작위초장진통국마약,재술후진통중장구유엄범적응용개치.
Background Liposomal bupivacaine is a kind of novel amide local anesthetics,and a slow-released bupivacaine produced by liposome technology.Many studies indicated that the analgesic time of liposomal bupivacaine could persist for 72 h.Objective To review the researches related to liposomal bupivacaine,especially the progress of liposomal bupivacaine for postsurgical analgesia.Content This review described the characteristics,pharmacokinetics,pharmacodynamics and safety of liposomal bupivacaine for postsurgical analgesia.Trend As one of the local anesthetics producing ultralong-acting analgesia,the wide application of liposomal bupivacaine is quite promising in postsurgical analgesia.
