CAJ | 학술논문

背景急性肺损伤(acute lung injury,ALI)是临床上常见的急重病症,致残率和致死率均极高.肺损伤时肺水平衡失调是其病理过程中十分重要的一环,以往人们对其原因的认识仅仅停留于肺毛细血管内皮细胞损伤而引起的通透性增加,如今,水通道蛋白(aquaporin,AQP)的发现及其研究的深入为ALI肺水肿的机制带来了新的视角. 目的了解AQP在不同诱因导致的ALI病理过程中的作用. 内容 AQP的一般特性、在肺组织中的分布及AQP在不同ALI模型中的作用. 趋势探索AQP在ALI病理过程中的作用,为临床上治疗ALI提供新的思路.
배경 급성폐손상(acute lung injury,ALI)시림상상상견적급중병증,치잔솔화치사솔균겁고.폐손상시폐수평형실조시기병리과정중십분중요적일배,이왕인문대기원인적인식부부정류우폐모세혈관내피세포손상이인기적통투성증가,여금,수통도단백(aquaporin,AQP)적발현급기연구적심입위ALI폐수종적궤제대래료신적시각. 목적 료해AQP재불동유인도치적ALI병리과정중적작용. 내용 AQP적일반특성、재폐조직중적분포급AQP재불동ALI모형중적작용. 추세 탐색AQP재ALI병리과정중적작용,위림상상치료ALI제공신적사로.
Background Acute lung injury (ALI) is a common syndrome with high mortality and disability rate.The imbalance of water in lung plays a significant role in the complicated pathological mechanisms of ALI.Dysfunction of lung vascular endothelial cells were thought to be accounted for the high permeability,however,the discovery of aquaporins (AQP),brings a novel perspective into this field.Objective Know about aquaporins' functions in different animal models of ALI.Content we will review aquaporins' general features,distribution in the lung,and functions in different animal models of acute lung injury.Trend Explore functions of aquaporins in the pathological mechanism of ALI,providing new thoughts for clinical treatments.