CAJ | 학술논문

背景谷氨酸离子型受体α-氯基-3羟基-5-甲基4异恶唑丙酸(α-amino-3-hydroxy-5-methylisoxazole4-propionate,AMPA)在缺血性脑损伤的发生发展过程中起重要作用.AMPA受体的GluR2亚基对其Ca2+通透性的调控逐渐受到人们的重视,这为缺血性脑损伤的治疗提供了新的契机. 目的探讨AMPA受体GluR2亚基在缺血性脑损伤过程中的调控作用,寻找新的缺血性脑损伤的治疗靶点. 内容综述缺血性脑损伤后AMPA受体Ca2+通透性与GluR2亚基的关系及影响因素. 趋向单纯针对GluR2亚基,阻断缺血/缺氧后因此产生的钙超载,这将成为治疗脑中风可能的有效靶点.
배경 곡안산리자형수체α-록기-3간기-5-갑기4이악서병산(α-amino-3-hydroxy-5-methylisoxazole4-propionate,AMPA)재결혈성뇌손상적발생발전과정중기중요작용.AMPA수체적GluR2아기대기Ca2+통투성적조공축점수도인문적중시,저위결혈성뇌손상적치료제공료신적계궤. 목적 탐토AMPA수체GluR2아기재결혈성뇌손상과정중적조공작용,심조신적결혈성뇌손상적치료파점. 내용 종술결혈성뇌손상후AMPA수체Ca2+통투성여GluR2아기적관계급영향인소. 추향 단순침대GluR2아기,조단결혈/결양후인차산생적개초재,저장성위치료뇌중풍가능적유효파점.
Background Ionotropic glutamate receptors (iGluRs),such as α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors,play an important role in the development and progress of ischemic cerebral injury.More attention has been paid to the regulation of AMPA receptor GluR2 subunit in Ca2+-Permeability of AMPA.Study in this regard will provide a new opportunity on the prevention and treatment of ischemic stroke.Objective To find a new therapeutic target of ischemic injury,we reviewed the role of the AMPA receptor GluR2 subunit in stroke.Content This review summarizes the relationship between GluR2 subunits and Ca2+-Permeability of AMPA as well as the other related factors.Trend Attenuating intracellular calcium overload via blockage of GluR2 subunits will become an effective therapeutic target for treatment of ischemic injury.