CAJ | 학술논문

背景机体内存在各种氧感受器和一系列的氧感受机制以维持体内氧的稳态,以避免因氧分压(partial pressure of oxygen,PO2)剧烈改变而造成机体损害.因此人们日益关注其具体的机制. 目的对已知的氧感受器及低氧感受和信号转导机制的基础研究和进展进行总结. 内容分别详细阐述各类已知的氧感受器,氧感受机制和低氧信号转导. 趋向低氧感受及缺氧反应的机制非常复杂,深入的研究对临床上预防、诊断和治疗缺氧性疾病有重要作用.
배경 궤체내존재각충양감수기화일계렬적양감수궤제이유지체내양적은태,이피면인양분압(partial pressure of oxygen,PO2)극렬개변이조성궤체손해.인차인문일익관주기구체적궤제. 목적 대이지적양감수기급저양감수화신호전도궤제적기출연구화진전진행총결. 내용 분별상세천술각류이지적양감수기,양감수궤제화저양신호전도. 추향 저양감수급결양반응적궤제비상복잡,심입적연구대림상상예방、진단화치료결양성질병유중요작용.
Background There are many different kinds of oxygen sensors and molecular mechanisms of response to hypoxia in the body to maintain the oxygen homeostasis,which can reduce or avoid damages caused by dramatic changes of partial pressure of oxygen (PO2).More and more attentions have been paid on these issues.Objective To summarize the known oxygen sensors and the advances in the mechanisms of response to hypoxia and signal transduction.Content Our review elaborates the different kinds of oxygen sensors,the mechanisms of response to hypoxia and signal transduction in detail.Trend The mechanisms of oxygen sensing and signal transduction are very complicated,further in-depth study will be very important in the prevention,diagnosis and treatment of hypoxia.