国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2014年
8期
761-763,768
,共4页
紧密连接%磷酸化%通透性
緊密連接%燐痠化%通透性
긴밀련접%린산화%통투성
Tight junctions%Phosphorylation%Permeability
背景 Occludin蛋白是一种跨膜连接蛋白,广泛地存在于脑、肝、肺、肾等重要器官的上皮细胞和内皮细胞中,与胞浆中的ZO-1、ZO-2、ZO-3,Claudin等蛋白共同参与细胞间的紧密连接(tight junctions,TJs).Occludin蛋白是组成TJs的最主要成分,其不同磷酸化状态直接影响TJs功能、结构及通透性. 目的 研究occludin蛋白不同磷酸化状态,提高对TJs的认识,深入了解通透性. 内容 介绍Occludin蛋白的生物学特性,Occludin蛋白不同磷酸化状态及Occludin蛋白磷酸化的临床意义. 趋向 对Occludin蛋白磷酸化状态及机制进行深入分析和研究,采取相应的防治措施,有助于减少脏器的损害,提高患者的生活质量.
揹景 Occludin蛋白是一種跨膜連接蛋白,廣汎地存在于腦、肝、肺、腎等重要器官的上皮細胞和內皮細胞中,與胞漿中的ZO-1、ZO-2、ZO-3,Claudin等蛋白共同參與細胞間的緊密連接(tight junctions,TJs).Occludin蛋白是組成TJs的最主要成分,其不同燐痠化狀態直接影響TJs功能、結構及通透性. 目的 研究occludin蛋白不同燐痠化狀態,提高對TJs的認識,深入瞭解通透性. 內容 介紹Occludin蛋白的生物學特性,Occludin蛋白不同燐痠化狀態及Occludin蛋白燐痠化的臨床意義. 趨嚮 對Occludin蛋白燐痠化狀態及機製進行深入分析和研究,採取相應的防治措施,有助于減少髒器的損害,提高患者的生活質量.
배경 Occludin단백시일충과막련접단백,엄범지존재우뇌、간、폐、신등중요기관적상피세포화내피세포중,여포장중적ZO-1、ZO-2、ZO-3,Claudin등단백공동삼여세포간적긴밀련접(tight junctions,TJs).Occludin단백시조성TJs적최주요성분,기불동린산화상태직접영향TJs공능、결구급통투성. 목적 연구occludin단백불동린산화상태,제고대TJs적인식,심입료해통투성. 내용 개소Occludin단백적생물학특성,Occludin단백불동린산화상태급Occludin단백린산화적림상의의. 추향 대Occludin단백린산화상태급궤제진행심입분석화연구,채취상응적방치조시,유조우감소장기적손해,제고환자적생활질량.
Background Occludin,one of integral membrane proteins,extensively exists in epithelial cells and endothelial cells of brain,liver,lung,kidney and other important organs,constituting tight junctions(TJs) with Claudin,ZO-1,ZO-2 and ZO-3 together.Phosphorylation of Occludin plays an important role in the regulation of TJs function,structure and permeability.Objective This paper aims to introduce different kinds of phosphorylation as to promote our knowledge of TJs and its permeability.Content This paper introduced biological characteristics of occludin,different kinds of phosphorylation and clinical significance of phosphorylation.Trend Further investigation on phosphorylation of occluding and its mechanism should be done to come up with proper measurement to decrease the injury of organs and improve the quality of the patients.
