CAJ | 학술논문

背景虽然恢复冠状动脉血流是挽救缺血心肌的重要措施,但是再灌注本身可以导致再灌注心律失常的发生,它与细胞内钙超载密切相关,钙/钙调蛋白依赖的钙调蛋白激酶Ⅱ(calcium/calmodulin-dependent protein kinaseⅡ,CaMKⅡ)是一种重要的丝/苏氨酸蛋白激酶,活化的CaMKⅡ通过多种方式调节胞内Ca2+的浓度. 目的探讨CaMKⅡ的结构、功能及CaMKⅡ磷酸化目的蛋白对再灌注心律失常的影响. 内容 CaMKⅡ可能是再灌注早期发生心律失常的重要信号分子,CaMKⅡ功能异常导致钙稳态失衡,是再灌注心律失常的重要原因. 趋向在缺血/再灌注的过程中选择合适的药物减轻钙超载,进而调节CaMKⅡ磷酸化目的蛋白的过程可能是未来治疗再灌注心律失常的重要靶点.
배경 수연회복관상동맥혈류시만구결혈심기적중요조시,단시재관주본신가이도치재관주심률실상적발생,타여세포내개초재밀절상관,개/개조단백의뢰적개조단백격매Ⅱ(calcium/calmodulin-dependent protein kinaseⅡ,CaMKⅡ)시일충중요적사/소안산단백격매,활화적CaMKⅡ통과다충방식조절포내Ca2+적농도. 목적 탐토CaMKⅡ적결구、공능급CaMKⅡ린산화목적단백대재관주심률실상적영향. 내용 CaMKⅡ가능시재관주조기발생심률실상적중요신호분자,CaMKⅡ공능이상도치개은태실형,시재관주심률실상적중요원인. 추향 재결혈/재관주적과정중선택합괄적약물감경개초재,진이조절CaMKⅡ린산화목적단백적과정가능시미래치료재관주심률실상적중요파점.
Background Although coronary reperfusion in ischaemic myocardium is the only prerequisite of heart salvage,but reperfusion may lead to reperfusion arrhythmias.Cytosolic Ca2+ overload is a significant mechanism for the severe life-threatening arrhythmias.Ca/calmodulin-dependent protein kinase Ⅱ (CaMK Ⅱ)is a serine/threonine kinase,which can adjust the intracellular calcium concentration ([Ca2+]i) via various pathways.Objective To explore the structure and function of CaMK Ⅱ and the impact of CaMK Ⅱ-dependent phosphorylation of the target protein on reperfusion arrhythmias.Content CaMK Ⅱ is a main signal molecule for early reperfusion arrhythmias.CaMK Ⅱ dysfunction can lead to deregulation of intracellular calcium homeostasis,finally cause reperfusion arrhythmias.Trend The choice of appropriate drug on the CaMK Ⅱ and its relevant target protein may be important therapeutic approach for reperfusion arrhythmias.