CAJ | 학술논문

背景铁是人体内极其重要的微量元素,参与了许多生物大分子的构成和基本的生命活动.人体内有一套精密完善的储存、转运、调控系统来维持铁稳态,当这一复杂的网络系统出现障碍时将会导致铁代谢紊乱. 目的综述脑内铁过载在神经退行性疾病发生发展中的重要作用. 内容通过对近年来相关文献的总结,主要对铁的转运相关蛋白、铁稳态的调节系统、转运机制等方面对铁过载的形成及其与神经退行性疾病的关系进行了初步探讨,脑内异常高浓度的铁参与了阿尔茨海默病、帕金森病等多种神经退行性疾病的病理过程. 趋向脑内铁过载引起神经退行性变的机制正被逐步阐明,但仍有许多问题有待解决.通过利用铁螫合剂来降低脑内铁过载可能是治疗这类疾病的一个潜在靶点.
배경 철시인체내겁기중요적미량원소,삼여료허다생물대분자적구성화기본적생명활동.인체내유일투정밀완선적저존、전운、조공계통래유지철은태,당저일복잡적망락계통출현장애시장회도치철대사문란. 목적 종술뇌내철과재재신경퇴행성질병발생발전중적중요작용. 내용 통과대근년래상관문헌적총결,주요대철적전운상관단백、철은태적조절계통、전운궤제등방면대철과재적형성급기여신경퇴행성질병적관계진행료초보탐토,뇌내이상고농도적철삼여료아이자해묵병、파금삼병등다충신경퇴행성질병적병리과정. 추향 뇌내철과재인기신경퇴행성변적궤제정피축보천명,단잉유허다문제유대해결.통과이용철석합제래강저뇌내철과재가능시치료저류질병적일개잠재파점.
Background As a crucial trace element in human body,iron is a component of many biological macromolecules and takes part in some basic life events.A sophisticated and sound system including iron storage,transport,regulation and control maintains iron homeostasis in the body.It will lead to iron metabolism disorder when the complex network is in problems.Objective To review the important roles of iron overload in brain during the genesis and development process of neurodegenerative diseases.Content The formation of iron overload in brain and its relationship with neurodegenerative diseases have be discussed by mainly concluding the issues in iron transporters,homeostatic regulatory system and transport mechanism.Aberrant high iron content in brain participates in pathological process of diverse neurodegenerative diseases,such as Alzheimer's disease and Parkinson's disease.Trend The mechanism of iron overload causing neurodegeneration is being clarifying,but remains many puzzles to be explored.It may become a potential target for neurodegeneration treatment by using iron chelators to reverse iron overload in brain.