CAJ | 학술논문

背景配对盒基因6(paired-box 6,Pax6)是配对同源框基因家族的一个高度保守成员,对于前脑发育具有重要影响,其缺失或突变可导致大脑结构异常和功能障碍. 目的对Pax6影响前脑神经发育及认知功能的研究进展作一系统阐述. 内容讨论Pax6的特性及其在前脑发育(主要是维持神经前体细胞特性、调节神经祖细胞增殖分化和神经元迁移等方面)中的作用,同时对Pax6相关的认知功能改变做一总结. 趋向对Pax6的功能及其作用机制的深入研究可能为一些Pax6相关的认知功能障碍提供新的治疗靶点.
배경 배대합기인6(paired-box 6,Pax6)시배대동원광기인가족적일개고도보수성원,대우전뇌발육구유중요영향,기결실혹돌변가도치대뇌결구이상화공능장애. 목적 대Pax6영향전뇌신경발육급인지공능적연구진전작일계통천술. 내용 토론Pax6적특성급기재전뇌발육(주요시유지신경전체세포특성、조절신경조세포증식분화화신경원천이등방면)중적작용,동시대Pax6상관적인지공능개변주일총결. 추향 대Pax6적공능급기작용궤제적심입연구가능위일사Pax6상관적인지공능장애제공신적치료파점.
Background Paired-box 6 (Pax6) is a highly conserved transcription member of homebox family with numerous actions in forebrain development,while missing or mutations of Pax6 can lead to abnormal structure and function of brain.Objective To review the role of Pax6 in forebrain development and cognitive function.Content In this literature,we will introduce the characteristics of Pax6,and the role of Pax6 in forebrain development,especially in the correct specification of neural progenitors,the balance between proliferation and differentiation of neural progenitor cells and the regulation of cortical neuronal migration.Moreover,we will also introduce the Pax6 related cognitive dysfunction in this review.Trend Further researches into this area may provide useful insights and directions into the Pax6 related cognitive dysfunction.