CAJ | 학술논문

背景钙黏蛋白(cadherin)是一类存在于细胞表面的跨膜糖蛋白,最初被认为是一种钙离子依赖性的细胞黏附分子,主要参与调节细胞黏附、促进细胞增殖、维持细胞极性等过程.近几年对cadherin调节突触发育和突触可塑性的研究取得了较大进展. 目的围绕cadherin在突触发育和突触可塑性过程中的作用及其相关分子机制简要作一综述,旨在为神经系统疾病的治疗提供理论依据. 内容 Cadherin的概述,cadherin在突触发育和突触可塑性调节中的作用以及相关分子机制,cadherin与神经疾病. 趋向随着cadherin在调节突触发育和突触可塑性过程中的研究不断深入,cadherin将成为治疗神经疾病的一个新型的靶点.
배경 개점단백(cadherin)시일류존재우세포표면적과막당단백,최초피인위시일충개리자의뢰성적세포점부분자,주요삼여조절세포점부、촉진세포증식、유지세포겁성등과정.근궤년대cadherin조절돌촉발육화돌촉가소성적연구취득료교대진전. 목적 위요cadherin재돌촉발육화돌촉가소성과정중적작용급기상관분자궤제간요작일종술,지재위신경계통질병적치료제공이론의거. 내용 Cadherin적개술,cadherin재돌촉발육화돌촉가소성조절중적작용이급상관분자궤제,cadherin여신경질병. 추향 수착cadherin재조절돌촉발육화돌촉가소성과정중적연구불단심입,cadherin장성위치료신경질병적일개신형적파점.
Background Cadherins are a group of transmembrane proteins that were originally identified as the cell-surface molecules responsible for Ca2+ dependent cell-cell adhesion.Cadherins play important roles in the regulation of cell adhesion,cell proliferation and cell polarity.Researches have made great progress on cadherins regulating synaptogenesis and synaptic plasticity in recent years.Objective In this article we overview the roles and molecular mechanisms of cdherins in synaptogenesis and synaptic plasticity processes,aims to provide theoretical basis for the treatment of diseases of the nervous system.Content The cadherin overview,the role of cadherin in regulating synaptogenesis and synaptic plasticity and related molecular mechanisms,cadherins and nervous diseases.Trend With the development of research of cadherin in the regulation of synaptogenesis and synaptic plasticity,cadherin will become a new therapeutic target for the treatment of neurological diseases.